Sex Differences in Pulmonary Hypertension
| Autor: | Kirsty M. Mair, Nina Denver, Rosemary Gaw, Hicham Labazi, Margaret R. MacLean, Hannah Morris |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Pulmonary Circulation Serotonin medicine.drug_class Idiopathic Pulmonary Hypertension Heart Ventricles Hypertension Pulmonary Bone Morphogenetic Protein Receptors Type II 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans 030212 general & internal medicine Obesity Estrogen synthesis Sex Characteristics business.industry Estrogens medicine.disease R1 Pulmonary hypertension BMPR2 medicine.anatomical_structure Endocrinology 030228 respiratory system Ventricle Estrogen Female business Signal Transduction |
| Zdroj: | Clinics in chest medicine. 42(1) |
| ISSN: | 1557-8216 |
| Popis: | Pulmonary arterial hypertension (PAH) occurs in women more than men whereas survival in men is worse than in women. In recent years, much research has been carried out to understand these sex differences in PAH. This article discusses clinical and preclinical studies that have investigated the influences of sex, serotonin, obesity, estrogen, estrogen synthesis, and estrogen metabolism on bone morphogenetic protein receptor type II signaling, the pulmonary circulation and right ventricle in both heritable and idiopathic pulmonary hypertension. |
| Databáze: | OpenAIRE |
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