Phase I/II Study of Stage III and IV Non-Small Cell Lung Cancer Patients Taking a Specific Dietary Supplement

Autor:	Vaclav Ryznar, Alexander S. Sun, Ales Vaclavik, Ching Hsu, Oldrich Ostadal, Thomas M. Fasy, Howard W. Bruckner, Hsu-Chong Yeh, Jaroslav Dusek, Ivan Dulik
Rok vydání:	1999
Předmět:	Adult Male Cancer Research medicine.medical_specialty Lung Neoplasms Medicine (miscellaneous) Gastroenterology Body Mass Index Magnoliopsida Carcinoma Non-Small-Cell Lung Internal medicine Vegetables medicine Carcinoma Humans Karnofsky Performance Status Stage (cooking) Lung cancer Survival analysis Aged Czech Republic Nutrition and Dietetics business.industry Weight change Respiratory disease Middle Aged medicine.disease Survival Analysis Surgery Oncology Dietary Supplements Toxicity Female business Body mass index
Zdroj:	Nutrition and Cancer. 34:62-69
ISSN:	1532-7914 0163-5581
Popis:	This phase I/II study evaluates the influence of selected vegetables (SV) that contain known antitumor components on the survival of stage III-IV non-small cell lung cancer (NSCLC) patients. All patients were treated with conventional therapies. SV was added to the daily diet of 5 stage I patients in the toxicity study group (TG) and 6 stage III and IV patients in the treatment group (SVG), but not to the diet of 13 stage III and IV patients in the control group (CG). Age, Karnofsky performance status (KPS), and body mass index of SVG and CG patients were comparable at entry. KPS declined in the CG patients (79 +/- 8 to 55 +/- 11) but improved in the SVG patients (75 +/- 8 to 80 +/- 13) one to three months after entry. Weight change in the CG, SVG, and TG patients was -12 +/- 5%, -2 +/- 2%, and +4 +/- 4%, respectively. The median survival time and mean survival of the CG patients were 4 and 4.8 months, but in the SVG patients they were 15.5 and 15 months (p < 0.01). No clinical signs of toxicity were found in the TG patients in the 24-month study period. Adding SV to the daily diet of NSCLC patients was found to be nontoxic and associated with improved weight maintenance, KPS, and survival of stage III and IV NSCLC patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e9e75aaa83adf94e1b15880c11cd30 https://doi.org/10.1207/s15327914nc340109 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.