Clostridium difficile in western Romania: unfavourable outcome predictors in a hospital for infectious diseases
| Autor: | Monica Licker, Alexandru Crişan, Ruxandra Jurac, Luminiţa Bădiţoiu, Ruxandra Laza, Voichiţa Lăzureanu, Emilian Damian Popovici |
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| Jazyk: | angličtina |
| Předmět: |
Male
Cross infection medicine.medical_specialty Veterinary medicine Medical microbiology Recurrence Risk Factors Nosocomial infections medicine Humans Prospective Studies Prospective cohort study Intensive care medicine Enterocolitis Pseudomembranous Aged Cross Infection Clostridioides difficile Romania business.industry Incidence Incidence (epidemiology) Emerging pathology Clostridium Infections Clostridium difficile Length of Stay Middle Aged Prognosis Clostridium difficile infections Hospitals Anti-Bacterial Agents Hospitalization Logistic Models Infectious Diseases Multivariate Analysis Tropical medicine Female business Research Article |
| Zdroj: | BMC Infectious Diseases |
| ISSN: | 1471-2334 |
| DOI: | 10.1186/s12879-015-0895-y |
| Popis: | Background The recent emergence of Clostridium difficile infections has included this condition among top nosocomial infections, due to its incidence, complications and important fatality, as well as to significant economic costs. Methods A prospective surveillance study of Clostridium difficile enterocolitis cases was performed in “Victor Babeş” Infectious Diseases Hospital in Timişoara (Romania) between 01.01.2013 - 30.06.2014, to estimate the incidence and to investigate the risk factors for unfavourable outcome and relapse. Dichotomous variables were compared by the chi-square test or Fisher exact test and the Mann–Whitney U test was used for continuous variables. Risk factors for unfavourable outcome/recurrence were investigated by logistic regression. Results 210 patients who experienced 219 episodes of infection with Clostridium difficile were identified, which gives an incidence per hospital of 20.57/15.70 to 1,000 discharged patients in 2013/2014 or 17.73/14.04 to 10,000 patient-days. In 162 patients (77.14%) the evolution was favourable while in 48 (22.86%) the outcome was unfavourable. In 42 patients (20.00%) recurrence of symptoms was identified. The multivariate analysis by logistic regression identified the ATLAS score (OR = 4.97, 95% CI = 2.12 to 11.66, p |
| Databáze: | OpenAIRE |
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