Changes in Mitral Annular Geometry and Dynamics With β-Blockade in Patients With Degenerative Mitral Valve Disease
| Autor: | Bo Li, Daniel B. Ennis, Ralph A.H. Stewart, Brett R. Cowan, Carissa G. Fonseca, Gabriel R. Rudd-Barnard, Alistair A. Young |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Adrenergic beta-Antagonists Regurgitation (circulation) Severity of Illness Index Ventricular Function Left Article Perimeter Double-Blind Method Mitral valve Internal medicine Image Processing Computer-Assisted Humans Medicine Radiology Nuclear Medicine and imaging In patient Metoprolol Mitral regurgitation Cross-Over Studies medicine.diagnostic_test business.industry Mitral Valve Insufficiency Magnetic resonance imaging Middle Aged Magnetic Resonance Imaging Crossover study medicine.anatomical_structure Cardiology Mitral Valve Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Circulation: Cardiovascular Imaging. 3:687-693 |
| ISSN: | 1942-0080 1941-9651 |
| DOI: | 10.1161/circimaging.110.959171 |
| Popis: | Background— Remodeling of the mitral annulus contributes to progression of mitral regurgitation (MR). In patients with moderate-to-severe MR, short-term treatment with β-blockers has been shown to increase left ventricular (LV) end-diastolic and end-systolic volume, and this could deleteriously increase mitral valve annular dimensions. The objective of this study was to quantify the effects of a short duration of β-blocker treatment on mitral annular dimensions and dynamics in patients with MR due to primary degenerative valve disease. Methods and Results— Twenty-five patients with moderate-to-severe degenerative MR and normal LV systolic function were studied in a double-blind crossover experiment using a β1-selective adrenergic blocker and placebo administered for 14±3 days. Cardiac MRI images were acquired after each treatment period to quantify mitral annular dimensions. At end diastole, there was no change in annular area (1659±331 versus 1632±299 mm 2 ; P P P P P P P P P Conclusions— Despite significant increases in LV end-diastolic and end-systolic volume, short-term β-blocker treatment of patients with moderate-to-severe MR reduced or preserved all mitral annular dimensions except SL at ES. |
| Databáze: | OpenAIRE |
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