Effects of a single dose of the acetylcholinesterase inhibitor velnacrine on recognition memory and regional cerebral blood flow in Alzheimer's disease
| Autor: | Guy M. Goodwin, K Siegfried, Hanson, Klaus P. Ebmeier, N J Dougal, D. J. Wyper, S M Curran, R Hunter, C. Murray, James Patterson |
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| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.drug_class Physostigmine Pharmacology Cognition Degenerative disease Double-Blind Method Alzheimer Disease Memory Memory improvement Humans Medicine Dementia Aged Recognition memory Tomography Emission-Computed Single-Photon business.industry Middle Aged medicine.disease Cerebral blood flow Acetylcholinesterase inhibitor Cerebrovascular Circulation Anesthesia Tacrine Cholinergic Female Cholinesterase Inhibitors Alzheimer's disease business |
| Zdroj: | Psychopharmacology. 108:103-109 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/bf02245293 |
| Popis: | The effects of a single oral dose of the acetylcholinesterase inhibitor velnacrine maleate on word and object recognition memory and regional uptake of 99mTc-exametazime were examined in patients with Alzheimer's disease. Word recognition memory was marginally improved 2 h after 75 mg velnacrine. With the same dose of velnacrine a relative increase in superior frontal uptake of 99mTc-exametazime was shown with single photon emission computed tomography (SPECT). This suggests increased regional perfusion and metabolism as a consequence of cholinergic stimulation. The effect did not co-vary with the degree of memory improvement, but, instead, more cognitively impaired patients showed a greater increase in tracer uptake after velnacrine, suggesting cholinergic hypersensitivity in the brains of Alzheimer patients. |
| Databáze: | OpenAIRE |
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