The impaired hyperglycemic peak as an additional indicator of Type 2 Diabetes development is misdetected
| Autor: | Rubén Román-Ramos, Héctor Miguel Trujillo-Arriaga |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty endocrine system diseases Metabolic Clearance Rate Early detection Type 2 diabetes Risk Assessment Sensitivity and Specificity Impaired glucose tolerance Internal medicine Humans Medicine Diagnostic Errors Oral glucose tolerance Aged Glucose tolerance test Plasma glucose medicine.diagnostic_test business.industry Reproducibility of Results nutritional and metabolic diseases Type 2 Diabetes Mellitus General Medicine Glucose Tolerance Test Middle Aged Prognosis medicine.disease Impaired fasting glucose Endocrinology Diabetes Mellitus Type 2 Hyperglycemia Sample Size Female business |
| Zdroj: | Medical Hypotheses. 62:268-274 |
| ISSN: | 0306-9877 |
| DOI: | 10.1016/s0306-9877(03)00338-4 |
| Popis: | Because there is not an optimal control for Type 2 diabetes mellitus (DM2), which encompasses about 90% of diagnosed diabetic patients, its prevention is key. Early detection of DM2 development can be made through impaired fasting glucose and/or impaired glucose tolerance diagnosis. However, cases exist when oral glucose tolerance test (OGTT) results show an hyperglycemic peakor =200 mg/dl as a unique alteration. This alteration is defined as impaired hyperglycemic peak (IHP) and should be considered as an additional early indicator of DM2 development. Because IHP is commonly misdetected by the standard OGTT, it is proposed that this misdetection can be solved using a closer sampled OGTT. The objective of this research was to detect IHP on 225 volunteers using a 10 min sampled OGTT during 2 h. Results show the existence of IHP in 25 cases, making it the most frequent and the less detected OGTT alteration. In eight of these cases, IHP could not have been detected using a standard OGTT, because at 30, 60 and 90 min, plasma glucose concentrations were200 200 mg/dl, however, at 40, 50, 70, and/or 80 min, IHP exists. |
| Databáze: | OpenAIRE |
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