Simian immunodeficiency virus from mandrill (Mandrillus sphinx) SIVmnd experimentally infects human and nonhuman primate cells
| Autor: | Issa Bedjabaga, Virginie Poaty-Mavoungou, Elie Mavoungou, Richard Onanga |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Primates animal diseases Immunology CD8-Positive T-Lymphocytes medicine.disease_cause Virus Replication Microbiology Virus Monocytes Cell Line Antigen biology.animal medicine Animals Humans Primary isolate Cells Cultured biology Macrophages Simian immunodeficiency virus Middle Aged biology.organism_classification Virology Mandrillus sphinx Rhesus macaque Infectious Diseases Leukocytes Mononuclear Simian Immunodeficiency Virus African Green Monkey Baboon Papio |
| Zdroj: | Microbes and infection. 3(8) |
| ISSN: | 1286-4579 |
| Popis: | This study set out to characterize the features of experimental infection by simian immunodeficiency virus in mandrill (SIVmnd) (Mandrillus sphinx), cynomolgus macaque (Macaca fascicularis), rhesus macaque (Macaca mulatta), chimpanzee (Pan troglodytes), African green monkey (Cercopithecus pygerythrus), baboon (Papio cynocephalus) and human cells. Purified cells were exposed to a primary isolate of SIVmnd grown in the infected mandrill peripheral blood mononuclear cells, and viral p27 gag antigen was quantitated by antigen capture ELISA. Human cells have been found to be infected by SIVmnd. SIVmnd infection in cynomolgus macaque, rhesus macaque, baboon, mandrill and human cells were more effective than in vervet and chimpanzee cells. In addition, the lymphocytic cell lines SupT1, CEMx174 and Molt4 clone 8 were consistently infected by SIVmnd, whereas U937, a monocytic cell line, was not. |
| Databáze: | OpenAIRE |
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