Predicting Survival of Small Intestine Neuroendocrine Tumors: Experience From a Major Referral Center
| Autor: | Celia M. Divino, Susheian Kelly, Sara T. Haile, Alexandra Z. Agathis, Kenneth Haines, Jeffrey J. Aalberg, Katherine G. Phillips, Michelle K. Kim |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Endocrinology Diabetes and Metabolism MEDLINE Kaplan-Meier Estimate Neuroendocrine tumors urologic and male genital diseases 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Internal medicine Intestinal Neoplasms Intestine Small Internal Medicine medicine Humans Young adult Referral and Consultation Aged Retrospective Studies Aged 80 and over Hepatology business.industry External validation Retrospective cohort study Nomogram Middle Aged medicine.disease Prognosis Small intestine Neuroendocrine Tumors Nomograms medicine.anatomical_structure 030220 oncology & carcinogenesis Referral center Chromogranin A 030211 gastroenterology & hepatology Female business |
| Zdroj: | Pancreas. 48(4) |
| ISSN: | 1536-4828 |
| Popis: | Neuroendocrine tumors (NETs) comprise 41.8% of small intestine malignancies. The NET nomogram is a 15-item prognostic tool that includes relevant factors for guiding management decisions. This is the first external validation of this tool among American patients at a tertiary treatment center.Patients who underwent surgical intervention from 2005 to 2017 were screened by retrospective chart review. Nomogram scores were calculated following the methods outlined by Modlin et al (Neuroendocrinology. 2010;92:143-157). Validation assessed the association between nomogram scores and survival using Wilcoxon test and Cox regression.Among the 121 patients selected, the NET nomogram significantly predicted survival as a continuous variable (P0.01) and when dichotomized using 83 points to distinguish low-risk versus high-risk groups (P0.01). However, the nomogram was not universally applicable as even at our specialty center, variables such as chromogranin A and urinary 5-hydroxyindoleacetic acid are not routinely collected, whereas others, like tumor grade, do not reflect the most recently updated classifications.The NET nomogram accurately identified patients at low and high risk of death. However, revision to update prognosticators could improve its usefulness for predicting survival of small intestine NETs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|