Quantification of gastric emptying caused by impaired coordination of pyloric closure with antral contraction: a simulation study
| Autor: | Gregory O'Grady, Yohsuke Imai, Leo K. Cheng, Shunichi Ishida, Taimei Miyagawa |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Contraction (grammar) Biomedical Engineering Biophysics Bioengineering computational fluid dynamics Impaired coordination gastric motor functions Biochemistry Gastroenterology digestive system Models Biological Biomaterials Bile reflux Internal medicine medicine Humans Antrum Life Sciences–Engineering interface Peristalsis Gastric emptying business.industry digestive oral and skin physiology Pylorus medicine.disease digestive system diseases Gastrointestinal Tract medicine.anatomical_structure bile reflux Duodenum rapid gastric emptying business Gastrointestinal Motility Biotechnology Research Article |
| Zdroj: | Journal of the Royal Society Interface |
| ISSN: | 1742-5662 |
| Popis: | Proper coordination of gastric motor functions is required for healthy gastric emptying. However, pyloric function may be impaired by functional disorders or surgical procedures. Here, we show how coordination between pyloric closure and antral contraction affects the emptying of liquid contents. We numerically simulated fluid dynamics using an anatomically realistic gastrointestinal geometry. Peristaltic contractions in the proximal stomach resulted in gastric emptying at a rate of 3–8 ml min −1 . When the pylorus was unable to close, the emptying rate increased to 10–30 ml min −1 , and instantaneous retrograde flow from the duodenum to the antrum occurred during antral relaxation. Rapid emptying occurred if the pylorus began to open during the terminal antral contraction, and the emptying rate was negative if the pylorus only opened during the antral relaxation phase. Our results showed that impaired coordination between antral contraction and pyloric closure can result in delayed gastric emptying, rapid gastric emptying and bile reflux. |
| Databáze: | OpenAIRE |
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