Clinicopathological risk factors for local recurrence in oral squamous cell carcinoma
| Autor: | Tohru Ikeda, Shuichi Fujita, Izumi Yoshitomi, Tokutarou Minamizato, Goro Kawasaki, Shin-ichi Yamada, Hisazumi Ikeda, Masahiro Umeda, Takeshi Shiraishi, Izumi Asahina, Hidenori Takahashi, Souichi Yanamoto |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Oncology medicine.medical_specialty Surgical margin medicine.medical_treatment Risk Factors Internal medicine Carcinoma medicine Humans Neoplasm Invasiveness Radical surgery Survival rate Aged Retrospective Studies Salvage Therapy Chemotherapy business.industry Incidence Standard treatment Incidence (epidemiology) Retrospective cohort study Middle Aged surgical margin medicine.disease Neoadjuvant Therapy oral squamous cell carcinoma Survival Rate stomatognathic diseases Logistic Models Otorhinolaryngology Chemotherapy Adjuvant Carcinoma Squamous Cell Female Mouth Neoplasms Surgery local recurrence Neoplasm Recurrence Local Oral Surgery business neoadjuvant chemotherapy |
| Zdroj: | International Journal of Oral and Maxillofacial Surgery. 41:1195-1200 |
| ISSN: | 0901-5027 |
| Popis: | Local recurrence of oral squamous cell carcinoma (OSCC) after primary surgery has been considered to be a poor prognostic entity in terms of survival rate. The purpose of this study is to evaluate the incidence of local recurrence and to identify significant risk factors for the local recurrence in OSCC. The authors retrospectively reviewed records for 187 patients who underwent radical surgery for OSCC. The local recurrence rate was 16.0% (30/187 patients) in this study. The survival rate of patients with local recurrence was 33.3%, which was significantly lower than that (94.3%) of patients without local recurrence. Pattern of invasion (POI), neoadjuvant chemotherapy (NAC), and the status of the surgical margin were identified as factors influencing local recurrence. In particular, NAC and the status of the surgical margin were independent risk factors by multivariate analysis. The deep margin was resected at a close site in many NAC-treated patients, suggesting that NAC may lead to local recurrence and poor outcomes. No efficacy of NAC was observed, suggesting that the standard treatment of oral cancers is surgery alone. International Journal of Oral and Maxillofacial Surgery, 41(10), pp.1195-1200; 2012 |
| Databáze: | OpenAIRE |
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