Multi-institutional experience of ductal carcinoma in situ in black vs white patients treated with breast-conserving surgery and whole breast radiation therapy
| Autor: | Hanmanth J. R. Neboori, Harrison X. Bai, Tiffanie K. Jones, Sharad Goyal, S.B. Motwani, Meena S. Moran, Cristiane Takita, C. Nelson, Bruce G. Haffty, Jean L. Wright, G.A. Hobeika |
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| Rok vydání: | 2012 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Multivariate analysis medicine.medical_treatment Black People Breast Neoplasms Mastectomy Segmental Disease-Free Survival White People Internal medicine medicine Breast-conserving surgery Humans Radiology Nuclear Medicine and imaging Estrogen Receptor Status Gynecology Analysis of Variance Radiation business.industry Cancer Neoplasms Second Primary Radiotherapy Dosage Ductal carcinoma Middle Aged medicine.disease Tumor Burden Radiation therapy Carcinoma Intraductal Noninfiltrating Cohort Hormonal therapy Female business |
| Zdroj: | International journal of radiation oncology, biology, physics. 84(3) |
| ISSN: | 1879-355X |
| Popis: | Purpose Given the paucity of data on racial disparities in ductal carcinoma in situ (DCIS), the data from a multi-institutional cohort of DCIS patients treated with breast-conserving surgery and whole breast radiation therapy (RT) were analyzed to determine whether racial disparities or differences exist. Methods and Materials A total of 533 white and 76 black DCIS patients from 3 university-based cancer centers were uniformly treated with breast-conserving surgery and RT. All patient data were collected and analyzed as a function of race. Results The median follow-up was 5.2 years. No significant racial differences were seen in tumor size, age at diagnosis, estrogen receptor status, necrosis, or grade (all P >.05). Of the treatment parameters, the RT dose delivered, boost, positive margin rates, frequency of hormone receptor status assessment, and receipt of hormonal therapy for the 2 cohorts did not significantly differ (all P >.05). The local relapse-free survival was similar at 5 years (96.1% and 98.1%, P =.399) and 10 years (92.8% vs 95.8%, P =.360), with no significant overall survival difference at 10 years (94.0% vs 88.9%, P =.290) between the white and black patients, respectively. On multivariate analysis, race was not an independent predictor of local relapse-free survival or overall survival when accounting for age, grade, and margin status. Conclusion In our large cohort of DCIS patients uniformly treated at 3 institutions with breast conservation without any apparent differences in treatment delivery parameters, we demonstrated that the clinical and pathologic features and local survival outcomes did not differ as a function of race. Our results suggest that when black patients with DCIS are appropriately selected for breast conservation and receive adjuvant RT without racial disparities in the treatment parameters, differences in the outcomes as a function of race do not exist. |
| Databáze: | OpenAIRE |
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