Omega-3 fatty acids in adipose tissue and risk of atrial fibrillation
| Autor: | Sam Riahi, Erik Berg Schmidt, Søren Lundbye-Christensen, Albert Marni Joensen, Thomas Andersen Rix, Pia Thisted Dinesen, Kim Overvad |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty eicosapentaenoic acid Docosahexaenoic Acids Clinical Biochemistry Adipose tissue Lower risk Biochemistry Gastroenterology Risk Assessment Cohort Studies FISH Internal medicine Atrial Fibrillation Medicine Humans N-3 fatty acids atrial fibrillation business.industry Proportional hazards model Atrial fibrillation General Medicine docosahexaenoic acid Middle Aged medicine.disease n-3 fatty acids Eicosapentaenoic acid fish oils adipose tissue N-3 FATTY-ACIDS Adipose Tissue Eicosapentaenoic Acid Docosahexaenoic acid Cohort Female HEALTH business |
| Zdroj: | Rix, T A, Dinesen, P, Lundbye-Christensen, S, Joensen, A M, Riahi, S, Overvad, K & Schmidt, E B 2022, ' Omega-3 fatty acids in adipose tissue and risk of atrial fibrillation ', European Journal of Clinical Investigation, vol. 52, no. 1, e13649 . https://doi.org/10.1111/eci.13649 Rix, T A, Dinesen, P T, Lundbye-Christensen, S, Joensen, A M, Riahi, S, Overvad, K & Schmidt, E B 2022, ' Omega-3 fatty acids in adipose tissue and risk of atrial fibrillation ', European Journal of Clinical Investigation, vol. 52, no. 1, e13649 . https://doi.org/10.1111/eci.13649 |
| ISSN: | 1365-2362 |
| DOI: | 10.1111/eci.13649 |
| Popis: | BACKGROUND: The aim of the present study was to examine the relation between adipose tissue content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and the risk of incident atrial fibrillation (AF).METHODS: In this case-cohort study based on data from the Danish Diet, Cancer and Health cohort, a total of 5,255 incident cases of AF was identified during 16.9 years of follow-up. Adipose tissue biopsies collected at baseline from all cases and from a randomly drawn subcohort of 3,440 participants were determined by gas chromatography. Data were analysed using weighted Cox regression.RESULTS: Data were available for 4,741 incident cases of AF (2,920 men and 1,821 women). Participants in the highest vs. the lowest quintile of EPA experienced a 45% lower risk of AF (men HR 0.55 (95% CI 0.41-0.69); women HR 0.55 (0.41-0.72)). For DHA, no clear association was found in men, whereas in women, participants in the highest quintile of DHA in adipose tissue had a 30% lower risk of incident AF (HR 0.70 (0.54-0.91)) compared to participants in the lowest quintile.CONCLUSIONS: A monotonous inverse association was found for the content of EPA in adipose tissue and risk of AF in both men and women. The content of DHA was inversely associated with the risk of AF in women, whereas no clear association was found for men. |
| Databáze: | OpenAIRE |
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