Utilizing Nurses to Staff an Ebola Vaccine Clinical Trial in Sierra Leone during the Ebola Outbreak
| Autor: | Wendi McDonald, Susan T. Goldstein, Rosalind J Carter, Patricia M Abu, Ayesha Koker, Joseph Edem-Hotah, Elizabeth T. Luman |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
030231 tropical medicine Personnel Staffing and Scheduling Nurses Supplement Articles Sierra leone Disease Outbreaks Sierra Leone 03 medical and health sciences 0302 clinical medicine medicine Immunology and Allergy Humans 030212 general & internal medicine Ebola Vaccines Clinical Trials as Topic Ebola vaccine Pan african business.industry Outbreak Hemorrhagic Fever Ebola Clinical trial Infectious Diseases Family medicine Workforce business |
| Zdroj: | The Journal of infectious diseases. 217(suppl_1) |
| ISSN: | 1537-6613 |
| Popis: | The Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE) was the first investigational vaccine trial conducted in Sierra Leone. STRIVE enrolled and vaccinated about 8000 healthcare and frontline workers and followed them for 6 months post-vaccination. Few in-country healthcare workers had previous experience with clinical trials. Retired nurses, veteran nurses, and recently graduated nurses were hired to fill critical study roles including study site management, screening participants for enrollment, vaccine administration, post-vaccination follow-up, and providing clinical nursing care and advice. In addition to role-specific training, nurses received general training on the study protocol and implementation, Good Clinical Practices, and documentation for clinical trials. Training in documentation and supervision was especially challenging; ongoing refresher training should be built into standard operating procedures for future similar clinical studies. Using local nurses to conduct study activities had both short- and long-term positive impacts for the study, the nurses themselves, the community, and the country’s health system. CLINICAL TRIALS REGISTRATION: ClinicalTrials.gov [NCT02378753] and Pan African Clinical Trials Registry [PACTR201502001037220]. |
| Databáze: | OpenAIRE |
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