In the rat forced swimming test, NA-system mediated interactions may prevent the 5-HT properties of some subacute antidepressant treatments being expressed
| Autor: | Luis Stinus, Manuel Bouvard, Jean-Philippe Rénéric |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Mirtazapine Dopamine Agents Mianserin Pharmacology Motor Activity Rats Sprague-Dawley Immobilization Norepinephrine Desipramine Fluoxetine medicine Animals Pharmacology (medical) Biogenic Monoamines Drug Interactions Oxidopamine Biological Psychiatry 5-HT receptor Adrenergic alpha-Antagonists Swimming Chemistry Depression Brain Antidepressive Agents Rats Psychiatry and Mental health Neurology Antidepressant Drug Therapy Combination Neurology (clinical) Serotonin Reuptake inhibitor human activities Selective Serotonin Reuptake Inhibitors medicine.drug Behavioural despair test |
| Zdroj: | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 12(2) |
| ISSN: | 0924-977X |
| Popis: | In the rat forced swimming test (FST), reuptake inhibitors selective of either serotonin (5-HT) or noradrenaline (NA) decrease immobility duration, and increase, respectively, swimming and climbing behaviour. In this study, an almost total 6-OHDA-induced NA-depletion prevented the behavioural effects of desipramine, but not fluoxetine. Interestingly, the serotonin/noradrenaline-reuptake-inhibitor milnacipran, as well as a (desipramine+fluoxetine) combination, could produce both swimming and climbing behaviour in NA-lesioned rats, but not in non-lesioned. The new antidepressant mirtazapine, which enhances both 5-HT and NA transmissions, supposedly through the antagonizing of α 2 -adrenoreceptors, dose-dependently reduced immobility and increased climbing behaviour. Interestingly, a (mirtazapine+fluoxetine) combination treatment resulted in additive anti-immobility effects and in the summation of fluoxetine-induced swimming with mirtazapine-induced climbing. Taken together, these data suggest that the NA system mediates presynaptic inhibiting interactions on the 5-HT system, that may involve α 2 -receptors, and that may limit the efficacy of mixed serotonin/noradrenaline reuptake inhibition in subacute antidepressant treatments. |
| Databáze: | OpenAIRE |
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