Myogenic response reduction by high blood glucose levels in human retinal arterioles
| Autor: | M, Blum, C, Brändel, U A, Müller |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Blood Glucose Male Retinal Artery Blood Pressure General Medicine Diagnostic Techniques Ophthalmological Muscle Smooth Vascular Arterioles 03 medical and health sciences Ophthalmology Glucose 0302 clinical medicine Vasoconstriction Hyperglycemia Hypertension 030221 ophthalmology & optometry Humans Female Exercise Intraocular Pressure 030217 neurology & neurosurgery |
| Zdroj: | European journal of ophthalmology. 15(1) |
| ISSN: | 1724-6016 |
| Popis: | The effect of elevated blood glucose level on the myogenic response of human retinal arterioles to acute increases in blood pressure is investigated. METHODS The vascular response to raised blood pressure (Bayliss effect) was measured in 12 healthy volunteers by use of the retinal vessel analyzer (RVA). For a 9-minute period an on-line measurement of the diameter of a retinal branch arteriole was performed. After the first 3 minutes (baseline measurement) a second phase with 3 minutes of isometric exercise caused an acute rise in blood pressure, followed by 3 minutes of recovery (phase III). After the first session 100 g glucose were administered per os. After 30 minutes blood glucose was measured again and an identical second session was performed with higher blood glucose levels. The Wilcoxon test was used for statistical analysis.During the first session a rise in mean arterial pressure of 22.8 (8.4) mmHg was followed by an arterial vasoconstriction of 6.6 (1.7) %. The administration of 100 g glucose resulted in a significant rise in blood glucose levels within 30 minutes between the two sessions (4.35 mmol/L vs 7.46 mmol/L) (p=0.002). The blood pressure rise of 25.7 (7.3) mm Hg in the second session was associated with a significant loss in arterial vasoconstriction of 2.3 (1.4) % (session I vs session II p=0.002).The myogenic response of the arterial wall in human retinal arterioles was significantly reduced during acute rise of blood glucose levels. (Eur J Ophthalmol 2005; 15: 56-61). |
| Databáze: | OpenAIRE |
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