The Impact of Repetitive Transcranial Magnetic Stimulation on Oxidative Stress in Subjects With Medication-Resistant Depression

Autor: Hayriye Baykan, Murat Alisik, Onur Durmaz, Ozcan Erel, Emre İspir
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Neuroscience (miscellaneous)
medicine.disease_cause
behavioral disciplines and activities
Gastroenterology
Depressive Disorder
Treatment-Resistant
Young Adult
03 medical and health sciences
0302 clinical medicine
Rating scale
Internal medicine
mental disorders
Oxidative stress marker
medicine
Homeostasis
Humans
Disulfides
Sulfhydryl Compounds
Young adult
Deep transcranial magnetic stimulation
Depression (differential diagnoses)
Aged
Psychiatric Status Rating Scales
chemistry.chemical_classification
business.industry
musculoskeletal
neural
and ocular physiology
Middle Aged
Transcranial Magnetic Stimulation
030227 psychiatry
Transcranial magnetic stimulation
Oxidative Stress
Psychiatry and Mental health
nervous system
chemistry
Thiol
Female
business
psychological phenomena and processes
030217 neurology & neurosurgery
Oxidative stress
Zdroj: The Journal of ECT. 34:127-131
ISSN: 1533-4112
1095-0680
DOI: 10.1097/yct.0000000000000467
Popis: Recent studies have shown that oxidative stress is involved in the neurobiology of depression. We investigated the effects of repetitive transcranial magnetic stimulation (rTMS) on a novel oxidative stress marker, thiol-disulfide homeostasis, in subjects with medication-resistant major depression (MRD).Twenty-six subjects with MRD underwent 15 rTMS sessions. Sociodemographic and baseline and post-rTMS Montgomery-Asberg Depression Rating Scale (MADRS) data were collected. Serum levels of native thiol, total thiol, and disulfide and their pairwise ratios were measured in baseline and post-rTMS blood samples.Serum levels of native and total thiol were significantly decreased after rTMS treatment (P0.05). Serum levels of thiol-disulfide and their ratios did not significantly differ (P0.05) between rTMS treatment responders (50% reduction in MADRS score, n = 11) and rTMS treatment nonresponders (n = 15). The percentage MADRS score changes did not correlate with the changes in the levels of serum thiol-disulfide from baseline to post-rTMS treatment in any subject (P0.05).Our results showed that rTMS treatment was effective in subjects with MRD and was associated with changes in serum thiol levels regardless of improvement in depression severity. Thus, the results did not support a possible therapeutic relationship between rTMS and thiol-disulfide homeostasis in subjects with MRD.
Databáze: OpenAIRE
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