Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions
| Autor: | C. Empig, Linda Easterbrook, Victoria A. Graham, Roger Hewson, Stuart D. Dowall, K. Schlunegger, K. Corbin-Lickfett, Christine B. Bruce |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
Bavituximab Article Subject viruses Immunology Fluorescent Antibody Technique Phosphatidylserines Antibodies Viral medicine.disease_cause Cell Line chemistry.chemical_compound VP40 Chlorocebus aethiops medicine Animals Humans Immunology and Allergy Vero Cells Cells Cultured Ebolavirus Ebola virus biology Virion virus diseases General Medicine Phosphatidylserine Hemorrhagic Fever Ebola Flow Cytometry Virology Hemorrhagic Fevers chemistry biology.protein Vero cell Antibody lcsh:RC581-607 Research Article Protein Binding medicine.drug |
| Zdroj: | Journal of Immunology Research Journal of Immunology Research, Vol 2015 (2015) |
| ISSN: | 2314-7156 2314-8861 |
| DOI: | 10.1155/2015/347903 |
| Popis: | Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against Ebola virus. A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been shown to have broad-spectrum antiviral activity. Here, we demonstrate that PGN401 specifically binds to Ebola virus and recognizes infected cells. Our study provides the first evidence of phosphatidylserine-targeting antibody reactivity against Ebola virus. |
| Databáze: | OpenAIRE |
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