Lack of serological evidence of Middle East respiratory syndrome coronavirus infection in virus exposed camel abattoir workers in Nigeria, 2016
| Autor: | Leo L.M. Poon, Daniel Kw Chu, Malik Peiris, Samuel Ms Cheng, S A Kuranga, Kin-ho Chan, Jamiu O Oladipo, Richard J. Webby, Ray T.Y. So, Eric H. Y. Lau, Ranawaka A.P.M. Perera |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
endocrine system medicine.medical_specialty camel Camelus Epidemiology Middle East respiratory syndrome coronavirus viruses abattoir 030231 tropical medicine coronavirus serology Nigeria Biology medicine.disease_cause Virus Serology 03 medical and health sciences 0302 clinical medicine MERS Zoonoses Virology Environmental health parasitic diseases medicine Animals Humans human Disease Reservoirs Coronavirus Middle East Transmission (medicine) Public health Public Health Environmental and Occupational Health virus diseases occupational exposure 030104 developmental biology Middle East Respiratory Syndrome Coronavirus Enzootic Coronavirus Infections Abattoirs Research Article |
| Zdroj: | Eurosurveillance |
| ISSN: | 1560-7917 |
| DOI: | 10.2807/1560-7917.es.2018.23.32.1800175 |
| Popis: | Middle East respiratory syndrome coronavirus (MERS-CoV) is an ongoing threat to global public health [1]. Serological and virological studies have shown evidence of MERS-CoV infection in camels in the Middle East, as well as in East, North and West Africa [2-5] and in Central Asia [6]. In spite of MERS-CoV being enzootic in camels in Africa, zoonotic MERS has not been reported from the African continent. Our recent genetic and phenotypic analysis of MERS-CoV from camels in West (Burkina Faso, Nigeria) Africa has shown that West African viruses were phylogenetically and phenotypically distinct from those associated with human disease in the Arabian Peninsula [7], raising the possibility that virus strain differences may be associated with differences in zoonotic potential. Abattoir workers with exposure to infected camels are a high-risk group for MERS-CoV infection in the Arabian Peninsula [8]. However, there is a paucity of serological data on MERS-CoV infection in people occupationally exposed to camels in Africa, a knowledge gap identified as a priority research question at a Food and Agriculture Organization of the United Nations-World Organisation for Animal Health-World Health Organization (FAO-OIE-WHO) Global Technical Meeting on MERS in September 2017 [1]. A previous study in Egypt in 2013 showed no serologic evidence of MERS-CoV among 179 serum samples from humans working in two camel abattoirs [3]. None of 760 people with household exposure to seropositive camels in Kenya in 2013 had evidence of MERS-CoV antibody [9]. Another study in Kenya in 2013–14 of 1,122 people (not with necessarily high exposure to camels) found two sera with low and inconclusive levels of neutralising antibody to MERS-CoV [10]. It remains important to carry out more sero-epidemiological studies on humans with occupational exposure to infected camels to understand whether or not zoonotic transmission is taking place in Africa. We therefore investigated for serological evidence of MERS-CoV infection of humans occupationally exposed to infected dromedary camels in an abattoir in Kano, Nigeria. |
| Databáze: | OpenAIRE |
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