| Autor: |
Xin, Cao, Hao, Shi, Wei-Qiang, Dou, Xin-Yao, Zhao, Ying-Xin, Zheng, Ya-Ping, Ge, Hai-Chao, Cheng, Dao-Ying, Geng, Jun-Ying, Wang |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
World Journal of Gastrointestinal Surgery. 14:1150-1160 |
| ISSN: |
1948-9366 |
| Popis: |
Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide. Transcatheter arterial chemoembolization (TACE) has been performed as a palliative treatment for patients with HCC. However, HCC is easy to recur after TACE. Magnetic resonance imaging (MRI) has clinical potential in evaluating the TACE treatment effect for patients with liver cancer. However, traditional MRI has some limitations.To explore the clinical potential of diffusion kurtosis imaging (DKI) in predicting recurrence and cellular invasion of the peritumoral liver zone of HCC after TACE.Seventy-six patients with 82 HCC nodules were recruited in this study and underwent DKI after TACE. According to pathological examinations or the overall modified response evaluation criteria in solid tumors (mRECIST) criterion, 48 and 34 nodules were divided into true progression and pseudo-progression groups, respectively. The TACE-treated area, peritumoral liver zone, and far-tumoral zone were evaluated on DKI-derived metric maps. Non-parametricDKI metrics, including mean diffusivity (MD), axial diffusivity (DA), radial diffusivity (DR), axial kurtosis (KA), and anisotropy fraction of kurtosis (Fak), showed statistically different values between the true progression and pseudo-progression groups (DKI has been demonstrated with robust performance in predicting the therapeutic response of HCC to TACE. Moreover, DKI might reveal cellular invasion of the peritumoral zone by molecular diffusion-restricted change. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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