PTIP promotes recurrence and metastasis of hepatocellular carcinoma by regulating epithelial-mesenchymal transition
| Autor: | Shusheng Leng, Mingyang Yang, Zhijun Zeng, Bo Lv, Bing Wang, Yanhua Zhao, Jiatian Yuan, Yunpeng Yang, Fan Jun, Jingfeng Zhao |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Pathology medicine.medical_treatment Metastasis 03 medical and health sciences 0302 clinical medicine hepatocelluar carcinoma Internal medicine microRNA medicine metastasis In patient Epithelial–mesenchymal transition miRNA business.industry medicine.disease digestive system diseases epithelial-mesenchymal transition (EMT) 030104 developmental biology 030220 oncology & carcinogenesis Hepatocellular carcinoma Ectopic expression PAX interacting protein1 (PTIP) Hepatectomy business Hepatocelluar carcinoma Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.16436 |
| Popis: | // Shusheng Leng 1, * , Mingyang Yang 2, * , Yanhua Zhao 3, * , Jingfeng Zhao 4 , Zhijun Zeng 5 , Yunpeng Yang 6 , Jiatian Yuan 1 , Bo Lv 1 , Fan Jun 1 and Bing Wang 1 1 General Surgery Department, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu 610081, China 2 Intensive Care Unit, The First People’s Hospital of Chengdu (Chengdu Combine Traditional Chinese and Western Medicine Hospital), Chengdu 610041, China 3 Department of Laboratory Medicine/Clinical Research Center of Laboratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China 4 General Surgery Department, Chongqing Dazu District People's Hospital, Chongqing 402360, China 5 Department of Geratic Surgery, Xiangya Hospital, Central South University, Changsha 410008, China 6 Department of Pathology, Affiliated Hospital/Clinical Medical College of Chengdu University, Chengdu 610081, China * These authors have contributed equally to this work Correspondence to: Shusheng Leng, email: lengshusheng@hotmail.com Jingfeng Zhao, email: 1398164216@qq.com Zhijun Zeng, email: Zengzhijun53@126.com Keywords: PAX interacting protein1 (PTIP), hepatocelluar carcinoma, miRNA, epithelial-mesenchymal transition (EMT), metastasis Received: October 11, 2016 Accepted: February 28, 2017 Published: March 22, 2017 ABSTRACT Hepatocellular carcinoma (HCC) is one of the most lethal tumors worldwide, which is mainly due to the high recurrence and metastasis rate after hepatectomy. In this study, we found that PTIP expression was dramatically upregulated in human HCC tissues and cell lines. High expression of PTIP was shown to be associated with aggressive clinicopathological features, including liver cirrhosis, vascular invasion and advanced stage. In addition, PTIP overexpression was independently associated with shorter survival and increased HCC recurrence in patients. Knockdown of the PTIP expression significantly inhibited invasion and metastasis in vitro and in vivo , whereas ectopic expression of PTIP significantly promoted invasion and metastasis. Mechanistically, PTIP promotes HCC progress by facilitating epithelial-mesenchymal transition (EMT). Notably, we also found that PTIP might increase miR-374a expression to promote EMT and metastasis in HCC. In summary, our study identified PTIP as a new potential prognostic indicator and therapeutic target for HCC. |
| Databáze: | OpenAIRE |
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