Etonogestrel implant in women with diabetes mellitus
| Autor: | Denisa Mendonça, J. Manuel Boavida, Marina Dingle, R. Duarte, Lisa Vicente |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Urology Body Mass Index Diabetes Complications chemistry.chemical_compound Internal medicine Diabetes mellitus medicine Contraceptive Agents Female Diabetes Mellitus Humans Hypoglycemic Agents Insulin Pharmacology (medical) Prospective Studies Etonogestrel Drug Implants Glycated Hemoglobin Desogestrel Triglyceride business.industry Obstetrics and Gynecology Lipid metabolism medicine.disease Lipid Metabolism Endocrinology Reproductive Medicine chemistry Albuminuria Carbohydrate Metabolism lipids (amino acids peptides and proteins) Female Implant medicine.symptom business medicine.drug Lipoprotein |
| Zdroj: | The European journal of contraceptionreproductive health care : the official journal of the European Society of Contraception. 13(4) |
| ISSN: | 1473-0782 |
| Popis: | To evaluate the effect of etonogestrel implant on the control of the carbohydrate and lipid metabolism and on the progression of vascular complications in diabetic women treated with insulin, and to assess the acceptability of this modality of contraception in these patients.Prospective-observational study of 23 women with insulin-treated diabetes. Clinical and metabolic evaluation was performed before and at 3, 6, 12, and 24 months after implant insertion. Changes from baseline were compared using the mixed effects models or Wilcoxon matched-pairs signed-rank tests.There were no significant changes in BMI, in daily insulin requirement and in mean HbA1c. There was a significant reduction of total serum cholesterol (TC) at 6 and 12 months, of triglyceride levels at 6, 12 and 24 months, and of high-density lipoprotein cholesterol (HDL-C) at 6, 12 and 24 months. Neither the low-density lipoprotein (LDL) levels nor the HDL/TC ratio changed. Albuminuria decreased significantly at 12 and 24 months. No deterioration of the retina was observed over the study period. Amenorrhoea and infrequent bleeding were the most common menstrual bleeding patterns. One woman discontinued the method due to frequent bleeding.We found no evidence of impaired control of the carbohydrate and lipid metabolism or aggravation of vascular lesions during the two years an etonogestrel implant was used by diabetic women. |
| Databáze: | OpenAIRE |
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