Protective Effect of Acetaminophen against Acute Gastric Mucosal Lesions Induced by Ischemia-Reperf usion in the Rat
| Autor: | Kouichirou Wada, Hironaka Kawasaki, Kentaro Nakamoto, Yoshinori Kamisaki, Tadao Itoh |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Lipid Peroxides Free Radicals Analgesic Ischemia Pharmacology Antioxidants Dinoprostone Lipid peroxidation chemistry.chemical_compound medicine Gastric mucosa Animals Rats Wistar Prostaglandin E2 Acetaminophen Lipid peroxide business.industry digestive oral and skin physiology General Medicine medicine.disease digestive system diseases Rats medicine.anatomical_structure chemistry Gastric Mucosa Reperfusion Injury Anesthesia Acute Disease business Reperfusion injury medicine.drug |
| Zdroj: | Pharmacology. 54:203-210 |
| ISSN: | 1423-0313 0031-7012 |
| DOI: | 10.1159/000139488 |
| Popis: | We examined the effect of acetaminophen, an analgesic and antipyretic drug, on acute gastric mucosal injury induced by ischemia-reperfusion in rats. Ischemia-reperfusion was induced by clamping the celiac artery for 30 min with a small clip. Sixty minutes after reperfusion, the total area of erosions was measured. Acetaminophen (300 and 500 mg/kg) administered intraperitoneally 90 min before the ischemia significantly reduced the total area of erosions. The drug also inhibited the increase in lipid peroxide levels induced by ischemia-reperfusion in the gastric tissue and the increase in lipid peroxidation caused by the hydroxyl radical, OH., in vitro. Gastric prostaglandin E2 (PGE2) contents tended to increase after ischemia-reperfusion in both control and acetaminophen-treated groups. A significant difference in gastric PGE2 contents between control and acetaminophen-treated groups was not observed. The results indicate that acetaminophen may protect the gastric mucosa against ischemia-reperfusion injury, probably by blocking hydroxyl-radical-induced membrane damage. |
| Databáze: | OpenAIRE |
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