Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer

Autor: Ralph W.H. Gottschalk, Matty P. Weijenberg, Adriaan P. de Bruïne, Frederik J. van Schooten, R. Alexandra Goldbohm, Manon van Engeland, Kim A.D. Wouters, Stefan de Vogel, Piet A. van den Brandt, Anton F.P.M. de Goeij
Přispěvatelé: RS: CAPHRI School for Public Health and Primary Care, RS: NUTRIM - R4 - Gene-environment interaction, Pathologie, Farmacologie en Toxicologie, Epidemiologie, RS: GROW - School for Oncology and Reproduction
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Cancer Research
Methyltransferase
genetic association
genotype
methyl metabolizing enzyme
DNA methyltransferase
cancer risk
LS - Life Style
Polymerase Chain Reaction
Epigenesis
Genetic
genetic heterogeneity
Diet and cancer
genetic variability
methionine synthase reductase gene
Promoter Regions
Genetic
cytosine
Netherlands
DNA methylation
biology
adult
allele
risk assessment
Middle Aged
cohort analysis
CRC
unclassified drug
enzyme activity
aged
female
Oncology
CpG site
priority journal
Health
Colorectal Neoplasms
Human
medicine.medical_specialty
phenotype
mthfr gene
colorectal cancer
Diet–gene interactions
genetic regulation
Folic Acid
promoter region
Gene interaction
male
Internal medicine
DNA methyltransferase 3B gene
thymine
medicine
methyl group
Humans
Genetic Predisposition to Disease
Diet-gene interactions
riboflavin
gene
pyridoxine
Medical disciplines: 700 [VDP]
methionine
Original Paper
Methyl donors
epigenetics
business.industry
gene interaction
Methyltransferases
DNA
methionine synthase gene
MTRR
heterozygote
major clinical study
protein intake
BSS - Behavioural and Societal Sciences
Vitamin B 6
digestive system diseases
Diet
Promoter hypermethylation
enzyme
Endocrinology
Methylenetetrahydrofolate reductase
folate metabolizing enzyme
biology.protein
CpG island
CpG Islands
methyltransferase
business
dietary intake
Zdroj: Cancer Causes and Control, 1, 22, 1-12
Cancer Causes & Control, 22(1), 1-12. Springer, Cham
Cancer Causes & Control
ISSN: 0957-5243
DOI: 10.1007/s10552-010-9659-6
Popis: Dietary methyl donors might influence DNA methylation during carcinogenesis of colorectal cancer (CRC). Among 609 CRC cases and 1,663 subcohort members of the Netherlands Cohort Study on diet and cancer (n = 120,852), we estimated CRC risk according to methyl donor intake across genotypes of folate metabolizing enzymes and methyltransferases. Although diet-gene interactions were not statistically significant, methionine intake was inversely associated with CRC among subjects having both common rs2424913 and rs406193 DNMT3B C > T genotypes (highest versus lowest tertile: RR = 0.44; p trend = 0.05). Likewise, vitamin B2 was modestly inversely associated among individuals with the MTHFR c.665CC (rs1801133) genotype (RR = 0.66; p trend = 0.08), but with a significant reduced risk when ≤ 1 rare allele occurred in the combination of folate metabolizing enzymes MTHFR, MTRR and MTR (RR = 0.30; p trend = 0.005). Folate or vitamin B6 were neither inversely associated with CRC nor was methyl donor intake associated with the CpG island methylator phenotype (CIMP). Despite the absence of heterogeneity across genotypes, might an effect of methyl donors on CRC be more pronounced among individuals carrying common variants of folate metabolizing enzymes or DNA methyltransferases. Combining genotypes may assist to reveal diet associations with CRC, possibly because rare variants of related genes may collectively affect specific metabolic pathways or enzymatic functions. © 2010 The Author(s). methyltransferase, 9037-42-7; cytosine, 71-30-7; methionine, 59-51-8, 63-68-3, 7005-18-7; methyltransferase, 9033-25-4; pyridoxine, 12001-77-3, 58-56-0, 65-23-6, 8059-24-3; riboflavin, 83-88-5; thymine, 65-71-4
Databáze: OpenAIRE
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