Behavioural and Psychological Symptoms of Alzheimer Type Dementia Are Not Correlated with Plasma Homocysteine Concentration
| Autor: | Naji Tabet, H Rafi, G Weaving, B Lyons, S A Iversen |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
Homocysteine Cognitive Neuroscience education Neuropsychological Tests Severity of Illness Index behavioral disciplines and activities Developmental psychology chemistry.chemical_compound Folic Acid Degenerative disease Alzheimer Disease mental disorders Severity of illness medicine Humans Dementia Psychological testing Vitamin B12 Aged Aged 80 and over Psychological Tests business.industry Mental Disorders Cognitive disorder medicine.disease humanities Vitamin B 12 Psychiatry and Mental health chemistry Female Geriatrics and Gerontology Alzheimer's disease business Clinical psychology |
| Zdroj: | Dementia and Geriatric Cognitive Disorders. 22:432-438 |
| ISSN: | 1421-9824 1420-8008 |
| DOI: | 10.1159/000095802 |
| Popis: | Background/Aims: Vitamin B12 and folate deficiencies have been associated with cognitive impairment and various psychiatric symptoms but not specifically with behavioural and psychological symptoms of dementia (BPSD). A limitation of previous studies in dementia was lack of concurrent homocysteine measurement especially as it may provide a better indicator of tissue activities of these vitamins. This study was designed to clarify whether a relationship exists between plasma homocysteine concentration and BPSD. Methods: Plasma homocysteine, serum vitamin B12 and folate were measured in23Alzheimer’s disease (AD) patients with BPSD and 27 AD patients without BPSD as determined through the use of the Neuropsychiatric Inventory (NPI). Blood levels of measured substances were also correlated with individual NPI scores and with cumulative NPI scores for different cluster of symptoms. Results: There was no significant difference (p = 0.956) in the mean plasma homocysteine levels between AD patients with BPSD (17.48 µmol/l) and AD patients without BPSD (17.34 µmol/l). Similarly, there was no significant difference between the two groups in the mean serum B12 (382.61 and 391.60 pg/ml, respectively) and folate (7.95 and 10.02 ng/ml, respectively). Mean levels for both vitamins were well within the laboratory reference range. Neither individual nor cluster NPI scores correlated significantly with plasma homocysteine. Conclusion: This study shows for the first time that BPSD are not associated with hyperhomocysteinaemia in Alzheimer dementia. Although previous studies have identified homocysteine as an independent risk factor in AD, the results reported here do not lend weight to an aetiological role for homocysteine specifically in BPSD. |
| Databáze: | OpenAIRE |
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