Investigation of ABCB1 gene polymorphism with colchicine response in Behçet’s disease
| Autor: | Hayriye Sarıcaoğlu, Gulten T, M Yilmaz, K Dilek, E B Baskan, H Z Y Ozturk, Kenan Aydogan, Tahsin Yakut, M Karkucak |
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| Přispěvatelé: | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı., Sarıcaoğlu, Hayriye, Yılmaz, Mediha, Karkucak, Mutlu, Öztürk, Hülya Z.Y., Yakut, Tahsin, Gülten, Tuna, Bülbül, Emel Başkan, Aydoğan, Kenan, Dilek, Kamil, AAH-1388-2021 |
| Rok vydání: | 2011 |
| Předmět: |
Male
Biochemistry & molecular biology Behcet's disease Disease Treatment response Gastroenterology chemistry.chemical_compound Genotype Colchicine Middle aged Drug withdrawal Genetics & heredity Multidrug-resistance gene General Medicine Randomized controlled trial Female Human medicine.drug Adult Diarrhea medicine.medical_specialty Efficacy Liver dysfunction Mdr1 Major clinical study Side effect P-glycoprotein Case control studies ABCB1 gene Article Association Internal medicine Multidrug resistance protein 1 Genetics medicine Humans ATP Binding Cassette Transporter Subfamily B Member 1 Polymorphism Allele Stomach disease Molecular Biology Allele frequency Behcet syndrome Genetic polymorphism business.industry MDR Gene Multidrug Resistance Protein 1 Restriction Fragment Length Polymorphisms Case-control study Leukopenia medicine.disease Gene frequency Adenosine stomatognathic diseases chemistry Clinical-relevance Case-Control Studies Polymorphism single nucleotide Genetic association Familial mediterranean fever business Behcet disease |
| Zdroj: | Genetics and Molecular Research. 10:1-6 |
| ISSN: | 1676-5680 |
| DOI: | 10.4238/vol10-1gmr824 |
| Popis: | Colchicine is commonly used in the treatment of Behçet's disease. However, some patients are unresponsive to colchicine treatment. Adenosine triphosphate-binding cassette subfamily B member 1 (ABCB1) transports colchicine out of cells. We investigated a possible association of C3435T polymorphism of the ABCB1 (MDR1) gene with colchicine response in patients with Behçet's disease. We randomly selected 97 patients with Behçet's disease, examined ABCB1 (MDR1) gene C3435T polymorphisms, and evaluated patient responses to colchicine. Forty-three patients were colchicine responsive, while the remaining 54 patients were unresponsive. No significant difference was found between genotypic and allelic frequencies of the ABCB1 C3435T polymorphisms in patients with Behçet's disease and healthy volunteers. Also, there was no significant difference among responsive and nonresponsive patients. We concluded that ABCB1 C3435T polymorphism is not associated with a colchicine response in patients with Behçet's disease. |
| Databáze: | OpenAIRE |
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