Soluble lectin-like oxidized LDL receptor-1 (sLOX-1) as a sensitive and specific biomarker for acute coronary syndrome--comparison with other biomarkers
| Autor: | Kazutaka Hayashida, Goro Kominami, Hirokazu Mitsuoka, Toru Kita, Noriaki Kume, Masaru Tanaka |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Acute coronary syndrome medicine.medical_treatment Coronary Angiography Fatty Acid-Binding Proteins Coronary artery disease Sensitivity and Specificity Troponin T Internal medicine Medicine Humans Acute Coronary Syndrome Plaque Diagnostic techniques biology business.industry Unstable angina Area under the curve Percutaneous coronary intervention Middle Aged Atherosclerosis medicine.disease Scavenger Receptors Class E Troponin Cardiology biology.protein Biomarker (medicine) Female Cardiology and Cardiovascular Medicine business Fatty Acid Binding Protein 3 Biomarkers |
| Zdroj: | Journal of cardiology. 56(2) |
| ISSN: | 0914-5087 |
| Popis: | SummaryBackgroundLectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) appears to be involved in atherosclerotic plaque vulnerability and rupture. Circulating soluble LOX-1 (sLOX-1) levels are dramatically elevated in patients with acute coronary syndrome (ACS), and its diagnostic sensitivity and specificity is superior to high-sensitivity C-reactive protein (hs-CRP). In this study, we have compared the diagnostic value of sLOX-1 for ACS with those of troponin T (TnT) and heart-type fatty acid binding protein (H-FABP).MethodsOne hundred and seven patients who underwent coronary angiography (CAG), including 18 ACS and 89 non-ACS patients were enrolled. Peripheral blood samples were obtained during the emergent or elective CAG. The non-ACS group consisted of 30 patients with normal CAG, 30 stable angina pectoris patients controlled by medical treatment, and 29 patients with stable angina who required elective coronary revascularization (percutaneous coronary intervention or coronary artery bypass graft).ResultsAge, gender, lipid profiles, or prevalence of diabetes, smoking, or hypertension were not significantly different between ACS and non-ACS. These factors did not significantly affect blood sLOX-1 levels. Circulating sLOX-1, TnT, and H-FABP levels were significantly higher in ACS than non-ACS. Area under the curve (AUC) values of the receiver-operating characteristic curves were 0.948, 0.704, and 0.691 for sLOX-1, TnT, and H-FABP, respectively. In a TnT-negative ( |
| Databáze: | OpenAIRE |
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