Link between Mild Traumatic Brain Injury, Poor Sleep, and Magnetic Resonance Imaging: Visible Perivascular Spaces in Veterans
Autor: | Craig D. Newgard, Madison Luther, Juan Piantino, Natalia M. Kleinhans, Elaine R. Peskind, Jeffrey J. Iliff, Lisa C. Silbert, Daniel Schwartz, Murray A. Raskind, Kathleen F. Pagulayan |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Adult
Male Sleep Wake Disorders 030506 rehabilitation medicine.medical_specialty Traumatic brain injury Head trauma Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Perivascular space Brain trauma Iraq War 2003-2011 Brain Concussion Veterans medicine.diagnostic_test Afghan Campaign 2001 business.industry Magnetic resonance imaging Original Articles medicine.disease Magnetic Resonance Imaging United States Poor sleep medicine.anatomical_structure Cardiology Glymphatic system Female Neurology (clinical) 0305 other medical science business Glymphatic System 030217 neurology & neurosurgery |
Zdroj: | J Neurotrauma |
Popis: | Impaired clearance of perivascular waste in the brain may play a critical role in morbidity after mild traumatic brain injury (mTBI). We aimed to determine the effect of mTBI on the burden of magnetic resonance imaging (MRI)-visible perivascular spaces (PVSs) in a cohort of U.S. military veterans and whether sleep modulates this effect. We also investigated the correlation between PVS burden and severity of persistent post-concussive symptoms. Fifty-six Iraq/Afghanistan veterans received 3 Tesla MRI as part of a prospective cohort study on military blast mTBI. White matter PVS burden (i.e., number and volume) was calculated using an established automated segmentation algorithm. Multi-variate regression was used to establish the association between mTBIs sustained in the military and PVS burden. Covariates included age, blood pressure, number of impact mTBIs outside the military, and blast exposures. Correlation coefficients were calculated between PVS burden and severity of persistent post-concussive symptoms. There was a significant positive relationship between the number of mTBIs sustained in the military and both PVS number and volume (p = 0.04). A significant interaction was found between mTBI and poor sleep on PVS volume (p = 0.04). A correlation was found between PVS number and volume, as well as severity of postconcussive symptoms (p = 0.03). Further analysis revealed a moderate correlation between PVS number and volume, as well as balance problems (p |
Databáze: | OpenAIRE |
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