The strength in numbers: comprehensive characterization of house dust using complementary mass spectrometric techniques

Autor: Adrian Covaci, Karl J. Jobst, Pawel Rostkowski, P. Booij, Nikiforos A. Alygizakis, Nikolaos S. Thomaidis, Merle Plassmann, François Lestremau, Peter Oswald, Sarit Kaserzon, Thomas Letzel, Chun Yang, Christine Gallampois, Hélène Budzinski, Peter Haglund, Jaroslav Slobodnik, Pim E.G. Leonards, Jörgen Magnér, Pernilla Bohlin Nizzetto, Ralph Hindle, Christoph Moschet, Hidenori Matsukami, Reza Aalizadeh, S. Grosse, Ildikó Ipolyi, Pamela Brunswick, Joaquin Beltran Arandes
Přispěvatelé: E&H: Environmental Bioanalytical Chemistry, AIMMS, Amsterdam Sustainability Institute, Norwegian Institute for Air Research (NILU), Department of Chemistry, Laboratoire de Physico -& Toxico Chimie des systèmes naturels (LPTC), Université Sciences et Technologies - Bordeaux 1-Centre National de la Recherche Scientifique (CNRS), Toxicological Centre, University of Antwerp (UA), QAEHS, Queensland Alliance for Environmental Health Science, The University of Queensland, Institute for Environmental Studies, University Amsterdam, Institut National de l'Environnement Industriel et des Risques (INERIS), Analytical Chemistry Research Group, Department of Biopolymer Chemistry, Technical University, Environmental Institute, MicroMachines Centre (MMC), Nanyang Technological University [Singapour], The NORMAN network is thanked for acting as the supporting organization of the study and the research group of Prof. Miriam Diamond, University of Toronto, Canada University of Toronto for the donation of the dust sample.
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Rostkowski, P, Haglund, P, Aalizadeh, R, Alygizakis, N, Thomaidis, N, Arandes, J B, Nizzetto, P B, Booij, P, Budzinski, H, Brunswick, P, Covaci, A, Gallampois, C, Grosse, S, Hindle, R, Ipolyi, I, Jobst, K, Kaserzon, S L, Leonards, P, Lestremau, F, Letzel, T, Magnér, J, Matsukami, H, Moschet, C, Oswald, P, Plassmann, M, Slobodnik, J & Yang, C 2019, ' The strength in numbers: comprehensive characterization of house dust using complementary mass spectrometric techniques ', Analytical and Bioanalytical Chemistry, vol. 411, no. 10, pp. 1957-1977 . https://doi.org/10.1007/s00216-019-01615-6
Analytical and Bioanalytical Chemistry, 411(10), 1957-1977. Analytical and Bioanalytical Chemistry
Analytical and bioanalytical chemistry
Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry, Springer Verlag, 2019, 411 (10), pp.1957-1977. ⟨10.1007/s00216-019-01615-6⟩
Repositori Universitat Jaume I
Universitat Jaume I
ISSN: 1618-2642
1618-2650
Popis: Untargeted analysis of a composite house dust sample has been performed as part of a collaborative effort to evaluate the progress in the field of suspect and nontarget screening and build an extensive database of organic indoor environment contaminants. Twenty-one participants reported results that were curated by the organizers of the collaborative trial. In total, nearly 2350 compounds were identified (18%) or tentatively identified (25% at confidence level 2 and 58% at confidence level 3), making the collaborative trial a success. However, a relatively small share (37%) of all compounds were reported by more than one participant, which shows that there is plenty of room for improvement in the field of suspect and nontarget screening. An even a smaller share (5%) of the total number of compounds were detected using both liquid chromatography–mass spectrometry (LC-MS) and gas chromatography–mass spectrometry (GC-MS). Thus, the two MS techniques are highly complementary. Most of the compounds were detected using LC with electrospray ionization (ESI) MS and comprehensive 2D GC (GC×GC) with atmospheric pressure chemical ionization (APCI) and electron ionization (EI), respectively. Collectively, the three techniques accounted for more than 75% of the reported compounds. Glycols, pharmaceuticals, pesticides, and various biogenic compounds dominated among the compounds reported by LC-MS participants, while hydrocarbons, hydrocarbon derivatives, and chlorinated paraffins and chlorinated biphenyls were primarily reported by GC-MS participants. Plastics additives, flavor and fragrances, and personal care products were reported by both LC-MS and GC-MS participants. It was concluded that the use of multiple analytical techniques was required for a comprehensive characterization of house dust contaminants. Further, several recommendations are given for improved suspect and nontarget screening of house dust and other indoor environment samples, including the use of open-source data processing tools. One of the tools allowed provisional identification of almost 500 compounds that had not been reported by participants. [Figure not available: see fulltext.].
Databáze: OpenAIRE
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