Central adiposity after breast cancer diagnosis is related to mortality in the Health, Eating, Activity, and Lifestyle study
| Autor: | Kathy B. Baumgartner, Leslie Bernstein, Ashley Wilder Smith, Stephanie M. George, Marian L. Neuhouser, Rachel Ballard-Barbash, Richard N. Baumgartner |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Blood Glucose
Cancer Research medicine.medical_specialty Waist Breast Neoplasms Motor Activity Article Breast cancer Insulin resistance Internal medicine medicine Humans Insulin Adiposity Aged C-Peptide Adiponectin Waist-Hip Ratio business.industry Hazard ratio Feeding Behavior Middle Aged medicine.disease Endocrinology Oncology Obesity Abdominal Cohort Homeostatic model assessment Female Insulin Resistance Waist Circumference business Body mass index |
| Zdroj: | Breast Cancer Research and Treatment. 146:647-655 |
| ISSN: | 1573-7217 0167-6806 |
| DOI: | 10.1007/s10549-014-3048-x |
| Popis: | We examined whether waist circumference (WC) and waist-to-hip ratio (WHR) after breast cancer diagnosis are associated with all-cause or breast cancer-specific mortality and explored potential biological pathways mediating these relationships. Our analysis included 621 women diagnosed with local or regional breast cancer who participated in the Health, Eating, Activity, and Lifestyle study. At 30 (±4) months postdiagnosis, trained staff measured participants’ waist and hip circumferences and obtained fasting serum samples for biomarker assays for assays of insulin, glucose, C-peptide, insulin growth factor-1 and binding protein-3, C-reactive protein (CRP), and adiponectin. We estimated multivariate hazard ratios (HR) and 95 % confidence intervals (CI) for death over *9.5 years of follow-up. After adjustment for measured body mass index, treatment, comorbidities, race/ethnicity, diet quality, and postdiagnosis physical activity, WC was positively associated with all-cause mortality (HR(q4:q1): 2.99, 95 % CI 1.14, 7.86) but its positive association with breast cancer-specificmortality was not statistically significant (HR(q4:q1): 2.69, 95 % CI 0.69, 12.01). WHR was positively associated with all-cause mortality (HR(q4:q1): 2.10, 95 % CI 1.08, 4.05) and breast cancer-specific mortality (HR(q4:q1): 4.02, 95 % CI 1.31, 12.31). After adjustment for homeostatic model assessment (HOMA) score and C-reactive protein, risk estimates were attenuated and not statistically significant. In this diverse breast cancer survivor cohort, postdiagnosis WC and WHR were associated with all-cause mortality. Insulin resistance and inflammation may mediate the effects of central adiposity on mortality among breast cancer patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink