Markers of Follicular Helper T Cells Are Occasionally Expressed in T-Cell or Histiocyte-Rich Large B-Cell Lymphoma, Classic Hodgkin Lymphoma, and Atypical Paracortical HyperplasiaA Diagnostic Pitfall For T-Cell Lymphomas of T Follicular Helper Origin
| Autor: | Carol J. Holman, Sergei Syrbu, Ibrahim Abukhiran |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
T Follicular Helper Cells
T cell Biology Lymphoma T-Cell 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor medicine Humans T-cell lymphoma CXCL13 music Neprilysin music.instrument Lymphoma T-Cell Peripheral Germinal center Histiocytes T-Lymphocytes Helper-Inducer General Medicine Hyperplasia Germinal Center medicine.disease Hodgkin Disease Immunohistochemistry Follicular hyperplasia Lymphoma medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research |
| Zdroj: | American Journal of Clinical Pathology. 156:409-426 |
| ISSN: | 1943-7722 0002-9173 |
| DOI: | 10.1093/ajcp/aqaa249 |
| Popis: | Objectives Follicular helper T cell (TFH) markers are expressed in angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma of the TFH phenotype (PTCL-TFH). However, differential expression and coexpression of these markers in benign and other malignant lymphoid proliferations have not been well studied. Methods We performed programmed death-1 (PD-1), C-X-C motif chemokine ligand 13 (CXCL13), inducible costimulator (ICOS), CD10, and B-cell lymphoma 6 protein (BCL-6) immunohistochemistry on AITL, PTCL not otherwise specified (PTCL-NOS), PTCL-TFH, T-cell or histiocyte-rich large B-cell lymphoma (THRLBCL), classic Hodgkin lymphoma (CHL), atypical paracortical hyperplasia (PCH), progressive transformation of germinal centers (PTGC), and reactive follicular hyperplasia (RFH). Results CXCL13 and ICOS were more sensitive but less specific for AITL than PD-1, CD10, and BCL-6. Moreover, 74% of AITL (none of PTCL-NOS or PTCL-TFH) coexpressed more than 2 TFH markers. In background T cells of THRLBCL, 70% of cases coexpressed more than 1 marker. The background T cells of CHL expressed all TFH markers except CD10 in all cases. In addition, 13% of PCH cases coexpressed more than 1 marker. In RFH and PTGC, all markers were expressed mainly in germinal centers with rare extrafollicular staining. Conclusions AITL, PTCL-NOS, and PTCL-TFH show differential expression of TFH markers. AITL frequently coexpresses more than 2 TFH markers. TFH markers can be expressed in PCH and in background T cells of THRLBCL and CHL. Consequently, caution should be used before a diagnosis of AITL is established, particularly with limited samples. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|