Effect of Quercetin Treatment on Mitochondrial Biogenesis and Exercise-Induced AMP-Activated Protein Kinase Activation in Rat Skeletal Muscle
| Autor: | Asuka Honda, Hiroyuki Masuda, Keiichi Koshinaka, Akiko Sato |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
AMPK
Male 0301 basic medicine medicine.medical_specialty Muscle Proteins lcsh:TX341-641 AMP-Activated Protein Kinases Article quercetin Mitochondrial Proteins 03 medical and health sciences 0302 clinical medicine AMP-activated protein kinase Endurance training Physical Conditioning Animal Internal medicine medicine Animals Citrate synthase rat heterocyclic compounds skeletal muscle Rats Wistar Muscle Skeletal Protein kinase A Organelle Biogenesis Nutrition and Dietetics exercise biology Chemistry Muscle adaptation Skeletal muscle 030229 sport sciences Mitochondria Muscle Rats 030104 developmental biology Endocrinology medicine.anatomical_structure Mitochondrial biogenesis biology.protein lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients Volume 12 Issue 3 Nutrients, Vol 12, Iss 3, p 729 (2020) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12030729 |
| Popis: | The purpose of this study was to evaluate the effect of chronic quercetin treatment on mitochondrial biogenesis, endurance exercise performance and activation levels of AMP-activated protein kinase (AMPK) in rat skeletal muscle. Rats were assigned to a control or quercetin group and were fed for 7 days. Rats treated with quercetin showed no changes in the protein levels of citrate synthase or cytochrome C oxidase IV or those of sirtuin 1, peroxisome proliferator-activated receptor gamma coactivator-1&alpha or phosphorylated AMPK. After endurance swimming exercise, quercetin-treated rats demonstrated no differences in blood and muscle lactate levels or glycogen utilization speed compared to control rats. These results indicate that quercetin treatment does not stimulate mitochondrial biogenesis in skeletal muscle and does not influence metabolism in a way that might enhance endurance exercise capacity. On the other hand, the AMPK phosphorylation level immediately after exercise was significantly lower in quercetin-treated muscles, suggesting that quercetin treatment might provide a disadvantage to muscle adaptation when administered with exercise training. The molecular results of this study indicate that quercetin treatment may not be advantageous for improving endurance exercise performance, at least after high-dose and short-term therapy. |
| Databáze: | OpenAIRE |
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