Comparing the effects of treatment with ammonium molybdate versus ammonium molybdate and phenoxy-2-methyl-2-propionic acid on liver functions in natural copper poisoning of sheep
| Autor: | Hasan Batmaz, Yiğit Kaçar, Onur Topal, Zafer Mecitoglu |
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| Přispěvatelé: | Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Anabilim Dalı., Mecitoğlu, Zafer, Topal, Onur, Kaçar, Yiğit, Batmaz, Hasan, AAH-1677-2021, S-8278-2017, AAH-4972-2021, AAH-1712-2021 |
| Rok vydání: | 2017 |
| Předmět: |
PMPA
040301 veterinary sciences medicine.medical_treatment Inorganic chemistry Agriculture dairy & animal science 0403 veterinary science Animal science Food Animals Phenoxy-2-methyl-2-propionic acid Peroxisome proliferator nafenopin Fatty liver Copper poisoning medicine Dairy-cows AST Saline Molybdenum Ammonium molybdate Sheep Chemistry Tetrathiomolybdate 0402 animal and dairy science Agriculture 04 agricultural and veterinary sciences Lipid-peroxidation 040201 dairy & animal science GGT Dry Matter Intake Feedlots Trace Elements Metabolism Propionic-acid Toxicosis Animal Science and Zoology Activated receptor-alpha Once daily Liver functions |
| Zdroj: | Small Ruminant Research. 150:93-96 |
| ISSN: | 0921-4488 |
| DOI: | 10.1016/j.smallrumres.2017.03.010 |
| Popis: | Aim of the presented study is to compare the effects of treatment with ammonium molybdate versus ammonium molybdate and phenoxy-2-methyl-2-propionic acid on liver functions in natural copper poisoning of sheep and overall treatment responses in sheep naturally poisoned with copper (Cu). Study was conducted on 80 yearlings aging between 6-9 months. AM + PMPA group (n =50) received ammonium molybdate and PMPA and AM group (n =30) received only ammonium molybdate. First blood samples were collected before the treatments. PMPA was administered once daily intramuscularly at dose of 10 mg/kg for the first three days of the study to AM + PMPA group. AM + PMPA and AM groups both received ammonium molybdate two times with one week interval at dose of 1.34 mg/kg (1 cc per 10 kg BW, of %1.34 ammonium molybdate in saline solution) subcutaneously. Second blood samples were collected from all 80 animals on day 21 of the study. Cu levels were measured in a subgroup of randomly selected 9 (5 from AM + PMPA and 4 from AM group) animals on days 0 and 21 of the study. Mean Cu levels were 158.25 +/- 14 mu g/dl and 156.75 +/- 9 mu g/dlon day 0 and 129 +/- 9 mu g/dl and 154.5 +/- 22 mu g/dl in AM + PMPA and AM group respectively. AST levels decreased from 502 +/- 67.2114 to 168 +/- 10.1 IU/L in AM + PMPA group (P < 0.001) and from 423 +/- 71.1 IU/Lto 202 +/- 17.1 IU/L in AM group (P = 0.005) on day 21 of the study. GGT levels were 250 +/- 24.2 IU/L and 248 +/- 28.1 IU/L on day 0 and decreased to 160 +/- 16.41 U/L and 166 +/- 22.2 IU/L on day 21 in AM + PMPA and AM group with significance of P=0.001 and P=0.037 respectively. Two animals from AM group and one from AM + PMPA group died during the study period. Based on the more pronounced decrease in AST and GGT levels in AM + PMPA group we conclude that PMPA has beneficial effects on liver functions in chronic copper poisoning of sheep probably as a result of decreased lipid peroxidation in hepatocytes and/or increased Cu elimination by cholerectic effects of PMPA. |
| Databáze: | OpenAIRE |
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