Long noncoding RNA GIHCG enhanced tongue squamous cell carcinoma progression through regulating miR-429
| Autor: | Qibao Wang, Long Ma, Zhibin Zuo, Lande Xue, Zuode Gong |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Tongue squamous cell carcinoma Biology In Vitro Techniques Biochemistry Metastasis 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Cell Movement Cell Line Tumor medicine Humans Molecular Biology Cell Proliferation Cell Cycle Cell Biology Cell cycle medicine.disease Long non-coding RNA Tongue Neoplasms Gene Expression Regulation Neoplastic MicroRNAs 030104 developmental biology Cell culture 030220 oncology & carcinogenesis Cancer research Disease Progression Ectopic expression RNA Long Noncoding Cancer development |
| Zdroj: | Journal of cellular biochemistry. 119(11) |
| ISSN: | 1097-4644 |
| Popis: | Long noncoding RNAs play essential roles in cancer development and progression. Here, we tried to investigate the role of GIHCG in the progression and metastasis of tongue squamous cell carcinoma (TSCC). In our study, we showed that that the expression level of GIHCG was upregulated in TSCC tissues and cell lines. In addition, we indicated that high GIHCG expression was positively associated with poor overall survival. Moreover, ectopic expression of GIHCG enhanced TSCC cell cycle, proliferation, and migration. Elevated expression of GIHCG inhibited the miR-429 expression in TSCC cells. We demonstrated that the expression level of miR-429 was lower in TSCC tissues and cell lines. Low miR-429 expression was positively associated with poor overall survival. We then determined the correlation between miR-429 and GIHCG expression levels. A statistically significantly inverse correlation was observed between miR-429 and GIHCG expression levels in TSCC tissues. In addition, overexpression of miR-429 suppressed the TSCC cell cycle, proliferation, and migration. Elevated expression of GIHCG promoted TSCC cell cycle, proliferation, and migration through regulating miR-429 expression. These results suggested that GIHCG increased TSCC progression through negative modulation of miR-429. Our results suggested that GIHCG/miR-429 might play a vital role in TSCC progression. |
| Databáze: | OpenAIRE |
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