Fibrillary glomerulonephritis with prevalent IgA deposition associated with undifferentiated connective tissue disease: A case report
| Autor: | A. Genderini, Antonella Tosoni, Giovanni Barbiano di Belgiojoso, Sabrina Caruso, Manuela Nebuloni |
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| Rok vydání: | 2009 |
| Předmět: |
Immunoglobulin A
Transplantation Pathology medicine.medical_specialty undifferentiated connective tissue disease electron microscopy biology medicine.diagnostic_test business.industry Fibrillary Glomerulonephritis Undifferentiated connective tissue disease Connective tissue Case Report Glomerulonephritis Context (language use) IgA nephropathy medicine.disease medicine.anatomical_structure Nephrology Intramembranous ossification medicine biology.protein Renal biopsy fibrillary glomerulonephritis business |
| Zdroj: | NDT Plus |
| ISSN: | 2048-8513 2048-8505 |
| DOI: | 10.1093/ndtplus/sfp125 |
| Popis: | We described a 41-year-old female patient, who presented with proteinuria occurring 5 years after the onset of an undifferentiated connective tissue disease (UCTD). At renal biopsy, a pattern of focal necrotizing glomerulonephritis with mesangial and parietal deposition of the IgA, C3 and K chains was observed. Electron microscopy showed organized fibrillary deposits in mesangial, subendothelial, intramembranous and subepithelial sites. Fibrils were randomly arranged, had no hollow core and had a diameter ranging between 10 and 23 nm. This case showed a rare combination of fibrillary glomerulonephritis and prevalent IgA deposition, in the clinical context of UCTD. |
| Databáze: | OpenAIRE |
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