Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH
Autor: | Ramon Róseo Paula Pessoa Bezerra de Menezes, Juliana Freire Chagas Vinhote, Bibiana Monson de Souza, Alice Maria Costa Martins, Dânya Bandeira Lima, Alexandre Havt, Valder N. Freire, Ricardo Pires dos Santos, Eudenilson L. Albuquerque, Mario Sergio Palma, Clarissa Perdigão Mello |
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Přispěvatelé: | Univ Fed Ceara, Universidade Estadual Paulista (Unesp), Univ Fed Rio Grande do Norte |
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Chagas disease Trypanosoma cruzi ved/biology.organism_classification_rank.species Wasp Venoms Venom Toxicology Parasitic infection Cell Line Microbiology 03 medical and health sciences parasitic diseases medicine Animals Antiparasitic agents Mastoparan biology ved/biology Wasp venom Glyceraldehyde-3-Phosphate Dehydrogenases biology.organism_classification medicine.disease Macaca mulatta Trypanocidal Agents Antiparasitic agent Molecular Docking Simulation 030104 developmental biology Immunology Molecular docking Intercellular Signaling Peptides and Proteins Peptides Polybia paulista Bacteria |
Zdroj: | Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
Popis: | Made available in DSpace on 2018-11-28T21:36:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-10-01 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) FUNCAP Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi. (C) 2017 Elsevier Ltd. All rights reserved. Univ Fed Ceara, Dept Physiol & Pharmacol, Fortaleza, Ceara, Brazil Univ Fed Ceara, Dept Clin & Toxicol Anal, Fortaleza, Ceara, Brazil Sao Paulo State Univ, Inst Biosci Rio Claro, Sao Paulo, Brazil Univ Fed Ceara, Comp Engn, Sobral, Ceara, Brazil Univ Fed Rio Grande do Norte, Dept Biophys & Pharmacol, Natal, RN, Brazil Univ Fed Ceara, Dept Phys, Fortaleza, Ceara, Brazil Sao Paulo State Univ, Inst Biosci Rio Claro, Sao Paulo, Brazil CNPq: 151182/2013-2 CNPq: 447592/2014-9 |
Databáze: | OpenAIRE |
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