Trypanocidal activity of mastoparan from Polybia paulista wasp venom by interaction with TcGAPDH

Autor: Ramon Róseo Paula Pessoa Bezerra de Menezes, Juliana Freire Chagas Vinhote, Bibiana Monson de Souza, Alice Maria Costa Martins, Dânya Bandeira Lima, Alexandre Havt, Valder N. Freire, Ricardo Pires dos Santos, Eudenilson L. Albuquerque, Mario Sergio Palma, Clarissa Perdigão Mello
Přispěvatelé: Univ Fed Ceara, Universidade Estadual Paulista (Unesp), Univ Fed Rio Grande do Norte
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Popis: Made available in DSpace on 2018-11-28T21:36:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-10-01 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) FUNCAP Chagas disease, considered a neglected disease, is a parasitic infection caused by Trypanosoma cruzi, which is endemic throughout the world. Previously, the antimicrobial effect of Mastoparan (MP) from Polybia paulista wasp venom against bacteria was described. To continue the study, we report in this short communication the antimicrobial effect of MP against Trypanosoma cruzi. MP inhibits all T. cruzi developmental forms through the inhibition of TcGAPDH suggested by the molecular docking. In conclusion, we suggest there is an antimicrobial effect also on T. cruzi. (C) 2017 Elsevier Ltd. All rights reserved. Univ Fed Ceara, Dept Physiol & Pharmacol, Fortaleza, Ceara, Brazil Univ Fed Ceara, Dept Clin & Toxicol Anal, Fortaleza, Ceara, Brazil Sao Paulo State Univ, Inst Biosci Rio Claro, Sao Paulo, Brazil Univ Fed Ceara, Comp Engn, Sobral, Ceara, Brazil Univ Fed Rio Grande do Norte, Dept Biophys & Pharmacol, Natal, RN, Brazil Univ Fed Ceara, Dept Phys, Fortaleza, Ceara, Brazil Sao Paulo State Univ, Inst Biosci Rio Claro, Sao Paulo, Brazil CNPq: 151182/2013-2 CNPq: 447592/2014-9
Databáze: OpenAIRE