Beneficial Effects of Gagam-Palmultang on Scopolamine-Induced Memory Deficits in Mice
| Autor: | Jin Ung Baek, Min Young Kwon, Malk Eun Pak, Byung Tae Choi, So Hyun Park, Yu Ri Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
MAPK/ERK pathway Article Subject Hippocampus Morris water navigation task Pharmacology CREB 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Neurotrophic factors Memory impairment Medicine PI3K/AKT/mTOR pathway biology business.industry lcsh:Other systems of medicine lcsh:RZ201-999 Acetylcholinesterase 030104 developmental biology Complementary and alternative medicine chemistry biology.protein business 030217 neurology & neurosurgery Research Article |
| Zdroj: | Evidence-based Complementary and Alternative Medicine : eCAM Evidence-Based Complementary and Alternative Medicine, Vol 2018 (2018) |
| ISSN: | 1741-427X |
| DOI: | 10.1155/2018/3479083 |
| Popis: | From text mining of Dongeuibogam, the 7 herbs in Palmultang can be considered effective candidates for memory enhancement. We sought to determine whether Gagam-Palmultang, comprising these 7 herbs, ameliorates scopolamine-induced memory impairment in mice, by focusing on the central cholinergic system and memory-related signaling molecules. Behavioral tests were performed after inducing memory impairment by scopolamine administration. The cholinergic system activity and memory-related molecules were examined in the hippocampus by enzyme-linked immunosorbent, western blot, and immunofluorescence assays. Gagam-Palmultang ameliorated scopolamine-induced memory impairment in the Morris water maze test, producing a significant improvement in the mean time required to find the hidden platform. Treatment with Gagam-Palmultang reduced acetylcholinesterase activity and expression in the hippocampus induced by scopolamine. The diminished phosphorylated phosphatidylinositide 3-kinase (PI3K), extracellular signal-regulated kinase (ERK), cAMP response element-binding protein (CREB), and mature brain-derived neurotrophic factor (mBDNF) expressions caused by scopolamine administration were attenuated by treatment with Gagam-Palmultang. This treatment also promoted neuronal cell proliferation in the hippocampus. Gagam-Palmultang has beneficial effects against scopolamine-induced memory impairments, which are exerted via modulation of the cholinergic system as well as the PI3K and ERK/CREB/BDNF signaling pathway. Therefore, this multiherb formula may be a useful therapeutic agent for diseases associated with memory impairments. |
| Databáze: | OpenAIRE |
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