A new approach using image analysis to assess pulmonary hypoplasia in the fetal lamb diaphragmatic hernia model
| Autor: | Juma Obayashi, Shigeyuki Furuta, Kei Ohyama, Kevin C. Pringle, Hideki Nagae, Takuya Kawaguchi, Kohei Kawaguchi, Yasuji Seki, Kunihide Tanaka, Hiroaki Kitagawa |
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| Rok vydání: | 2019 |
| Předmět: |
Lung Diseases
03 medical and health sciences Pulmonary hypoplasia 0302 clinical medicine Pregnancy Prenatal Diagnosis 030225 pediatrics Animals Medicine Abnormalities Multiple Diaphragmatic hernia Lung volumes Lung Fetus Sheep Bronchography business.industry Congenital diaphragmatic hernia General Medicine medicine.disease Magnetic Resonance Imaging Disease Models Animal medicine.anatomical_structure Animals Newborn Pediatrics Perinatology and Child Health Pregnancy Animal Gestation Female 030211 gastroenterology & hepatology Surgery Hernias Diaphragmatic Congenital business Nuclear medicine |
| Zdroj: | Pediatric Surgery International. 35:1131-1136 |
| ISSN: | 1437-9813 0179-0358 |
| DOI: | 10.1007/s00383-019-04543-9 |
| Popis: | In congenital diaphragmatic hernia (CDH), there is pulmonary hypoplasia (PH) and also pulmonary vascular and bronchial abnormalities. Few studies have investigated bronchial maldevelopment in CDH. We evaluated bronchial area (BA) by bronchography in a fetal lamb DH model to develop a measure of PH. We created DH in fetal lambs at 75 days gestation, delivering by cesarean section and killing them at term (DH, n = 12). Normal term fetuses provided controls (C, n = 5). We measured total lung volume (TLV) and performed barium bronchography. Using image analysis, BA, total lung area (TLA) and bronchial area/lung area ratio (B/L ratio) were calculated. Student’s T test (p |
| Databáze: | OpenAIRE |
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