Functional Variants of Lipid Level Modifier MLXIPL, GCKR, GALNT2, CILP2, ANGPTL3 and TRIB1 Genes in Healthy Roma and Hungarian Populations
| Autor: | Luca Jaromi, Renata Szalai, Lili Magyari, Petra Matyas, Béla Melegh, Erzsebet Kovesdi, Balazs Duga, Anita Maász, Katalin Sumegi, Ingrid Janicsek |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Cancer Research Genotype Population Single-nucleotide polymorphism Protein Serine-Threonine Kinases Biology Polymerase Chain Reaction Polymorphism Single Nucleotide Pathology and Forensic Medicine chemistry.chemical_compound Gene Frequency ANGPTL3 Ethnicity Humans Allele education Gene Allele frequency Triglycerides Adaptor Proteins Signal Transducing Angiopoietin-Like Protein 3 Genetics Hungary education.field_of_study Triglyceride Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Lipid level Intracellular Signaling Peptides and Proteins General Medicine Middle Aged humanities Angiopoietin-like Proteins Oncology chemistry N-Acetylgalactosaminyltransferases Female Angiopoietins Microtubule-Associated Proteins Biomarkers Polymorphism Restriction Fragment Length |
| Zdroj: | Pathology & Oncology Research. 21:743-749 |
| ISSN: | 1532-2807 1219-4956 |
| DOI: | 10.1007/s12253-014-9884-5 |
| Popis: | The role of triglyceride metabolism in different diseases, such as cardiovascular or cerebrovascular diseases is still under extensive investigations. In genome-wide studies several polymorphisms have been reported, which are highly associated with plasma lipid level changes. Our goal was to examine eight variants: rs12130333 at the ANGPTL3, rs16996148 at the CILP2, rs17321515 at the TRIB1, rs17145738 and rs3812316 of the MLXIPL, rs4846914 at GALNT2, rs1260326 and rs780094 residing at the GCKR loci. A total of 399 Roma (Gypsy) and 404 Hungarian population samples were genotyped using PCR-RFLP method. Significant differences were found between Roma and Hungarian population samples in both MLXIPL variants (C allele frequency of rs17145738: 94.1% vs. 85.6%, C allele frequency of rs3812316: 94.2% vs. 86.8% in Romas vs. in Hungarians, p |
| Databáze: | OpenAIRE |
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