The Serum Metabolite Response to Diet Intervention with Probiotic Acidified Milk in Irritable Bowel Syndrome Patients Is Indistinguishable from that of Non-Probiotic Acidified Milk by 1H NMR-Based Metabonomic Analysis
| Autor: | Niels Chr. Nielsen, Johan Olsson, Simon Metz Pedersen, Hanne Christine Bertram, Magnus Simren, Anders Malmendal, Henrik J. Andersen, Ulla Svensson, Lena Öhman |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male multivariate data analysis Magnetic Resonance Spectroscopy Adolescent Metabolite Irritable colon 1H-NMR spectroscopy lcsh:TX341-641 Article law.invention Irritable Bowel Syndrome Young Adult chemistry.chemical_compound Probiotic Blood serum Symptom relief law Animals Humans Medicine metabonomics Lactic Acid Food science Irritable bowel syndrome Aged lactate Nutrition and Dietetics 3-Hydroxybutyric Acid business.industry food and beverages Middle Aged medicine.disease Lactic acid Milk probiotics chemistry Symptom Evaluations Female business acidified milk products lcsh:Nutrition. Foods and food supply Biomarkers Food Science |
| Zdroj: | Pedersen, S M M, Nielsen, N C, Andersen, H J, Olsson, J, Simrén, M, Öhman, L, Svensson, U, Malmendal, A & Bertram, H C 2010, ' The Serum Metabolite Response to Diet Intervention with Probiotic Acidified Milk in Irritable Bowel Syndrome Patients is Indistinguishable from that of Non-Probiotic Acidified Milk by 1 H NMR-Based Metabonomic Analysis ', Nutrients, vol. 2, no. 11, pp. 1141-1155 . https://doi.org/10.3390/nu2111141 Nutrients, Vol 2, Iss 11, Pp 1141-1155 (2010) Nutrients Volume 2 Issue 11 Pages 1141-1155 Pedersen, S M, Nielsen, N C, Andersen, H J, Olsson, J, Simrén, M, Öhman, L, Svensson, U, Malmendal, A & Bertram, H C 2010, ' The Serum Metabolite Response to Diet Intervention with Probiotic Acidified Milk in Irritable Bowel Syndrome Patients is indistiguishanble from that of Non-Probiotic Acidified Milk by 1H NMR-based Metabonomic Analysis ', Nutrients, vol. 2, pp. 1141-1155 . |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu2111141 |
| Popis: | The effects of a probiotic acidified milk product on the blood serum metabolite profile of patients suffering from Irritable Bowel Syndrome (IBS) compared to a non-probiotic acidified milk product was investigated using (1)H NMR metabonomics. For eight weeks, IBS patients consumed 0.4 L per day of a probiotic fermented milk product or non-probiotic acidified milk. Both diets resulted in elevated levels of blood serum L-lactate and 3-hydroxybutyrate. Our results showed identical effects of acidified milk consumption independent of probiotic addition. A similar result was previously obtained in a questionnaire-based evaluation of symptom relief. A specific probiotic effect is thus absent both in the patient subjective symptom evaluations and at the blood serum metabolite level. However, there was no correspondence between symptom relief and metabolite response on the patient level. |
| Databáze: | OpenAIRE |
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