Chronic treatment with cyclosporine affects systemic purinergic parameters, homocysteine levels and vascular disturbances in rats
| Autor: | Ana Elisa Böhmer, Giordano Gubert Viola, Liz Marina Brum, André Mendes Ribeiro Corrêa, David Driemeier, Paulo Jaconi Saraiva, Luis Valmor Cruz Portela, Débora Guerini Souza, Jean Pierre Oses, Diogo O. Souza |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Endothelium Homocysteine Toxicology chemistry.chemical_compound Adenine nucleotide medicine.artery Internal medicine medicine Animals Rats Wistar Aorta Chromatography High Pressure Liquid Adenine Nucleotides Chemistry Vascular disease Hydrolysis Receptors Purinergic General Medicine medicine.disease Adenosine Rats Endocrinology medicine.anatomical_structure Immunology Cyclosporine Corn oil medicine.drug Artery |
| Zdroj: | Chemico-Biological Interactions. 188:15-20 |
| ISSN: | 0009-2797 |
| Popis: | Vascular disease is a major cause of morbidity and mortality among transplanted recipients and cyclosporine (CsA) treatment has been consistently implicated in this event. In this study we assessed total blood homocysteine levels (tHcy), ecto-nucleotidase activities and adenine nucleotide/nucleoside levels searching for parameters related to the mechanisms of vascular damage induced by chronic CsA treatment in non-transplanted rats. Thirty male Wistar rats were divided in three groups: control group treated with corn oil, CsA 5mg/kg and CsA 15 mg/kg, administered by daily gastric gavage during 8 weeks. CsA 15 mg/kg treatment increased blood levels of tHcy. Both CsA treatments (5mg/kg and 15 mg/kg) decreased adenine nucleotides hydrolysis by ecto-nucleotidases in serum, which negatively correlated with tHcy levels (r: -0.74, r: -0.63 and r: -0.63, p |
| Databáze: | OpenAIRE |
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