Demonstration of a receptor on rabbit neutrophils for chemotactic peptides
| Autor: | Candace B. Pert, Richard J. Freer, Srinivasabhatt Aswanikumar, Barbara A. Corcoran, Elliot Schiffmann, Elmer L. Becker, H.J. Showell, Alan R. Day |
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| Rok vydání: | 1977 |
| Předmět: |
Blood Platelets
Erythrocytes Neutrophils Receptors Drug Biophysics Peptide Plasma protein binding Biology Binding Competitive Biochemistry Structure-Activity Relationship Animals Structure–activity relationship Lymphocytes Receptor Molecular Biology chemistry.chemical_classification Chemotaxis Cell Membrane Brain Rabbit (nuclear engineering) Dipeptides Cell Biology Kinetics A-site chemistry Rabbits Oligopeptides Drug metabolism Protein Binding |
| Zdroj: | Biochemical and Biophysical Research Communications. 74:810-817 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/0006-291x(77)90375-8 |
| Popis: | [3H]formylNorleu-Leu-Phe, a potent leucocyte chemoattractant, binds specifically to a site on rabbit neutrophils with an affinity of 1.5 × 10−9 M. Other acylated peptide chemoattractants displace this binding at concentrations closely related to those levels required to elicit chemotaxis. The binding fulfills the major criteria for demonstration of specific receptor sites and indicates that a natural bacterial product and synthetic formyl-peptides produce chemotaxis by the same receptor mechanism. |
| Databáze: | OpenAIRE |
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