Differential expression of two scribble isoforms during Drosophila embryogenesis
| Autor: | Mingfa Li, Joachim Marhold, Bernard M. Mechler, Anastasios Gatos, Istvan Török |
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| Rok vydání: | 2001 |
| Předmět: |
Central Nervous System
Gene isoform SCRIB Embryology DNA Complementary animal structures Molecular Sequence Data Morphogenesis Genes Insect Neuroblast Animals Drosophila Proteins Protein Isoforms Genes Tumor Suppressor Peripheral Nerves Cloning Molecular biology Germ-band extension Alternative splicing Gene Expression Regulation Developmental Membrane Proteins Drosophila embryogenesis biology.organism_classification Immunohistochemistry Molecular biology Alternative Splicing Drosophila Drosophila melanogaster Developmental Biology |
| Zdroj: | Mechanisms of Development. 108:185-190 |
| ISSN: | 0925-4773 |
| DOI: | 10.1016/s0925-4773(01)00482-8 |
| Popis: | The tumour suppressor gene scribble (scrib) is required for epithelial polarity and growth control in Drosophila. Here, we report the identification and embryonic expression pattern of two Scrib protein isoforms resulting from alternative splicing during scrib transcription. Both proteins are first ubiquitously expressed during early embryogenesis. Then, during morphogenesis each Scrib protein displays a specific pattern of expression in the central and peripheral nervous systems, CNS and PNS, respectively. During germ band extension, the expression of the longer form Scrib1 occurs predominantly in the neuroblasts derived from the neuro-ectoderm and becomes later restricted to CNS neurones as well as to the pole cells in the gonads. By contrast, the shorter form Scrib2 is strongly expressed in the PNS and a subset of CNS neurones. |
| Databáze: | OpenAIRE |
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