Sex difference after acute myocardial infarction patients with a history of current smoking and long-term clinical outcomes: Results of KAMIR Registry

Autor:	Sung Jin Hong, Seunghwan Kim, Jung Sun Kim, Yong Hoon Kim, Donghoon Choi, Young Guk Ko, Ae-Young Her, Yangsoo Jang, Chul Min Ahn, Myung Ho Jeong, Byeong Keuk Kim, Myeong Ki Hong
Rok vydání:	2022
Předmět:	medicine.medical_specialty business.industry Hazard ratio Female group General Medicine Disease medicine.disease Confidence interval Internal medicine medicine Cardiology Male group Stent thrombosis Myocardial infarction Risk factor Cardiology and Cardiovascular Medicine business
Zdroj:	Cardiology Journal. 29:954-965
ISSN:	1898-018X 1897-5593
Popis:	Background: The contribution of sex as an independent risk factor for cardiovascular disease still remains controversial. The present study investigated the impact of sex on long-term clinical outcomes in Korean acute myocardial infarction (AMI) patients with a history of current smoking on admission after drug-eluting stents (DESs). Methods: A total of 12,565 AMI patients (male: n = 11767 vs. female: n = 798) were enrolled. Major adverse cardiac events (MACEs) comprising all-cause death, recurrent myocardial infarction (Re-MI), and any repeat revascularization were the primary outcomes that were compared between the two groups. Probable or definite stent thrombosis (ST) was the secondary outcome. Results: After adjustment, the early (30 days) cumulative incidences of MACEs (adjusted hazard ratio [aHR]: 1.457; 95% confidence interval [CI]: 1.021–2.216; p = 0.035) and all-cause death (aHR: 1.699; 95% CI: 1.074–2.687; p = 0.023) were significantly higher in the female group than in the male group. At 2 years, the cumulative incidences of all-cause death (aHR: 1.561; 95% CI: 1.103–2.210; p = 0.012) and Re-MI (aHR: 1.880; 95% CI: 1.089–2.974; p = 0.022) were significantly higher in the female group than in the male group. However, the cumulative incidences of ST were similar between the two groups (aHR: 1.207; 95% CI: 0.583–2.497; p = 0.613). Conclusions: The female group showed worse short-term and long-term clinical outcomes compared with the male group comprised of Korean AMI patients with a history of current smoking after successful DES implantation. However, further studies are required to confirm these results.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d7639f4d212996cd59dcf6d42570e6 https://doi.org/10.5603/cj.a2020.0185 Zobrazit plný text záznamu