Observations on Several Experimental Models of Hypertension in Mice
| Autor: | Akio Ebihara, B.L. Martz |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
medicine.medical_specialty
Hypertension Renal medicine.medical_treatment Enucleation Urology Sodium Chloride Renal Artery Obstruction Injections Intramuscular Nephrectomy Constriction Mice Renal Artery medicine.artery Animals Medicine Renal artery Desoxycorticosterone Desoxycorticosterone Acetate business.industry Myocardium Adrenalectomy Brain Blood Pressure Determination Blood pressure medicine.anatomical_structure Liver Anesthesia Hypertension Female Cardiology and Cardiovascular Medicine business Spleen Artery |
| Zdroj: | Japanese Heart Journal. 12:275-280 |
| ISSN: | 1348-673X 0021-4868 |
| Popis: | A cuff and tail microphonic method (Friedman-Freed's technique) was applied to determine the systolic blood pressure of unanesthetized mice. It ranged from 94 to 132mm.Hg with a mean of 109mm.Hg. Chronic hypertension and hypertensive cardiovascular changes were induced in mice by a) constriction of unilateral renal artery with contralateral nephrectomy (Goldblatt), b) complete ligation of a branch of unilateral artery with contralateral nephrectomy (Loomis), c) unilateral adrenal enucleation with contralateral nephrectomy and adrenalectomy plus salt (Skelton), and by d) desoxycorticosterone acetate plus salt. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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