Molecular and Evolutionary History of Melanism in North American Gray Wolves
| Autor: | Claudia Greco, Elaine A. Ostrander, Hua Tang, Gregory S. Barsh, Douglas W. Smith, Tovi M. Anderson, Marco Musiani, Ettore Randi, Jennifer A. Leonard, Badri Padhukasahasram, Sophie I. Candille, Bridgett M. vonHoldt, Daniel R. Stahler, Robert K. Wayne, Carlos Bustamante |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Gene Flow
beta-Defensins Molecular Sequence Data ved/biology.organism_classification_rank.species Zoology Locus (genetics) Coyotes Polymorphism Single Nucleotide Article Linkage Disequilibrium Gene flow Dogs Phylogenetics Animals Selection Genetic Hair Color Domestication Ecosystem Phylogeny Sequence Deletion Melanins Wolves Multidisciplinary Natural selection biology Pigmentation ved/biology Melanism biology.organism_classification Gray wolf Biological Evolution Phenotype Canis Haplotypes Mutation Agouti Signaling Protein Receptor Melanocortin Type 1 |
| Zdroj: | Science. 323:1339-1343 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1165448 |
| Popis: | Morphological diversity within closely related species is an essential aspect of evolution and adaptation. Mutations in the Melanocortin 1 receptor ( Mc1r ) gene contribute to pigmentary diversity in natural populations of fish, birds, and many mammals. However, melanism in the gray wolf, Canis lupus , is caused by a different melanocortin pathway component, the K locus, that encodes a beta-defensin protein that acts as an alternative ligand for Mc1r. We show that the melanistic K locus mutation in North American wolves derives from past hybridization with domestic dogs, has risen to high frequency in forested habitats, and exhibits a molecular signature of positive selection. The same mutation also causes melanism in the coyote, Canis latrans , and in Italian gray wolves, and hence our results demonstrate how traits selected in domesticated species can influence the morphological diversity of their wild relatives. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|