What does the HAMD mean?
| Autor: | Stefan Leucht, Armin Szegedi, Rolf R. Engel, Hein Fennema, Peter Lepping, Marion Kaspers-Janssen |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychometrics Test validity Severity of Illness Index Internal medicine mental disorders Hamd Severity of illness medicine Humans Clinical significance Psychiatric Status Rating Scales Depressive Disorder Major Hamilton Rating Scale for Depression Reproducibility of Results Middle Aged medicine.disease Clinical trial Psychiatry and Mental health Clinical Psychology Treatment Outcome Major depressive disorder Female Psychology Clinical psychology |
| Zdroj: | Journal of affective disorders. 148(2-3) |
| ISSN: | 1573-2517 |
| Popis: | Little is known about the clinical relevance of the Hamilton Rating Scale for Depression (HAMD-17) total scores. It is unclear how total scores translate into clinical severity, or what commonly used measures for response (reduction from baseline of ≥ 50% in the total score) and remission (total HAMD-17 score ≤ 7) mean from a clinical perspective. We therefore compared: (a) the percentage and absolute change in the HAMD-17 total scores with Clinical Global Impression-Improvement (CGI-I); (b) the absolute and percentage change in the HAMD-17 total scores with Clinical Global Impression-Severity (CGI-S) absolute change; and (c) the percentage and absolute change in the HAMD-17 total scores with CGI-I in the subgroups of patients with ≤ median andmedian HAMD-17 total scores at baseline. The method used was equipercentile linking of HAMD-17 and CGI ratings from 43 drug trials in patients with Major Depressive Disorder (MDD) (n = 7131). Our results confirm the validity of the commonly used measures for remission and response in MDD trials: a CGI-I score of 2 ('much improved') corresponded to a reduction from baseline of50% and60%, and a CGI-I score of 1 ('very much improved') to a reduction of75% and85%. The CGI-S score of 1 ('normal., not at all ill') corresponded to the HAMD-17 total score of5 and the CGI-S score of 2 ('borderline mentally ill') to the score between 6 and 8. An effect of baseline illness severity was observed. |
| Databáze: | OpenAIRE |
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