A Prospective Multicenter Observational Study of Venous Thromboembolism after Gastric Cancer Surgery (SHISA-1601)
| Autor: | Hiroyuki Ohta, Hiroshi Tsuchihashi, Katsushi Takebayashi, Takeshi Tatsuta, Shoichi Nishimura, Hiroshi Okauchi, Satoshi Murata, Sachiko Kaida, Tomoharu Shimizu, Tsuyoshi Yamaguchi, Masaji Tani, Koichiro Murakami, Toru Miyake, Masayasu Kawasaki |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Blood transfusion medicine.medical_treatment Soluble fibrin Asymptomatic Gastroenterology Risk Factors Stomach Neoplasms Gastrectomy Internal medicine D-dimer medicine Humans Venous thromboembolism (VTE) Prospective Studies cardiovascular diseases business.industry Area under the curve Anticoagulants Cancer Venous Thromboembolism Odds ratio equipment and supplies medicine.disease ROC Curve Surgery Observational study medicine.symptom Gastric cancer business Biomarkers |
| Zdroj: | European Surgical Research. 62:10-17 |
| ISSN: | 1421-9921 0014-312X |
| DOI: | 10.1159/000514309 |
| Popis: | Introduction:This study aimed to clarify the frequency and risk factors of intercurrent venous thromboembolism (VTE) in patients undergoing major curative gastric cancer surgery. Methods:This prospective, multicenter, observational study included patients with gastric cancer who underwent radical gastrectomy at 5 hospitals between June 2016 and May 2018. Patients who were preoperatively administered anticoagulants were excluded. Results:A total of 126 patients were eligible to participate. VTE occurred within 9 days postoperatively in 5 cases (4.0%; 2 symptomatic and 3 asymptomatic). Postoperative day (POD) 1 plasma D-dimer and soluble fibrin (SF) levels were significantly higher in the VTE group than in the non-VTE group. Receiver-operating characteristic curve (ROC) analysis indicated a statistically significant ability of POD 1 D-dimer and SF levels to predict postoperative VTE development after gastrectomy; this finding was reflected by an area under the curve (AUC) of 0.97 (95% CI 0.92-1.0) and 0.87 (95% CI 0.74-1.0), respectively. Cutoff values of D-dimer (24.6 µg/mL) and SF (64.1 µg/mL) were determined. Intraoperative blood transfusion (odds ratio [OR] 7.86), POD 1 D-dimer ≥24.6 µg/mL (OR 17.35), and POD 1 SF ≥64.1 µg/mL (OR 19.5) were independent predictive factors for postoperative VTE (p < 0.05). Conclusion:VTE occurred in 4.0% patients (1.6% symptomatic and 2.4% asymptomatic) after gastric cancer surgery; however, with an early diagnosis and anticoagulant therapy, no patients experienced progression. Careful observation of patients with a high risk for VTE, including intraoperative blood transfusion and high POD 1 D-dimer or SF levels, would contribute to the early detection of VTE. |
| Databáze: | OpenAIRE |
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