Budesonide prevents but does not reverse sustained airway hyperresponsiveness in mice
| Autor: | David S. Southam, Simon Young, Mark D. Inman, J. Wattie, Russ Ellis |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Pulmonary and Respiratory Medicine
Budesonide Time Factors medicine.drug_class medicine.disease_cause Mice Allergen Adrenal Cortex Hormones Respiratory Hypersensitivity medicine Animals Lung Asthma Inflammation Mice Inbred BALB C Bronchus business.industry Respiratory disease Allergens respiratory system medicine.disease Pathophysiology Bronchodilator Agents respiratory tract diseases Disease Models Animal Treatment Outcome medicine.anatomical_structure Immunology Corticosteroid Female Collagen business Airway medicine.drug |
| Zdroj: | European Respiratory Journal. 32:970-978 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/09031936.00125307 |
| Popis: | Despite the effectiveness of corticosteroids at resolving airway inflammation, they are only moderately effective at attenuating airway hyperresponsiveness (AHR). The extent to which corticosteroids are able to reverse or inhibit the development of sustained AHR is not known. The present study aimed to determine whether budesonide can resolve and or prevent the development of sustained AHR in mice. Mice were chronically exposed to allergen and treated with budesonide either: 1) briefly during the final weeks of exposure to allergen; 2) prolonged concurrently throughout exposure to allergen; or 3) delayed following final exposure to allergen. AHR was assessed 24 h (brief treatment) or 4 weeks (prolonged concurrent and delayed treatments) following final exposure to allergen. Brief budesonide intervention significantly attenuated the inflammation-associated AHR assessed immediately following final exposure to allergen. Similarly, prolonged concurrent budesonide treatment prevented the development of sustained AHR. Delayed budesonide intervention, however, did not resolve sustained AHR. In conclusion, the early introduction and, importantly, the persistence of corticosteroid treatment prevented the development of sustained airway hyperresponsiveness; however, the inability of corticosteroids to reverse established airway dysfunction indicates a limitation in their use for the complete, long-term management of airway hyperresponsiveness. |
| Databáze: | OpenAIRE |
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