The prognostic value of DNA ploidy and S-phase estimate in primary breast cancer: a prospective study
| Autor: | P. Vassilakos, S. Wieser, B. Dieterich, X. Albe, F. Krauer, R. Friedrich |
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| Rok vydání: | 1995 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty Pathology Mammary gland Breast Neoplasms Biology Adenocarcinoma S Phase Internal medicine medicine Carcinoma Humans Prospective cohort study Survival analysis Univariate analysis Ploidies Carcinoma Ductal Breast DNA Neoplasm Cell cycle Progesterone Receptor Status medicine.disease Prognosis Survival Analysis medicine.anatomical_structure Lymphatic Metastasis Multivariate Analysis Female Receptors Progesterone Cytometry |
| Zdroj: | International journal of cancer. 63(1) |
| ISSN: | 0020-7136 |
| Popis: | In this prospective study, the independent prognostic value of DNA ploidy in combination with the major clinico-pathological characteristics (histological grade, nodal status, tumor size, estrogen and progesterone receptor status, number of tumors, multicentricity, lympho-vascular infiltration) was evaluated in a series of 399 breast-cancer patients. The mean follow-up time was 4.5 years. The DNA content was measured using image cytometry on fresh tumor samples. The overall survival of tetraploid and slowly proliferating diploid cases was significantly different compared with that of aneuploid and rapidly proliferating diploid cases (p = 0.0002). Thus, DNA ploidy combined with S-phase estimate (DNA histogram type) appeared to be good prognostic factors. In a multivariate survival analysis, DNA histogram type was not an independent prognostic factor unless the histological grade was excluded. This effect of DNA histogram type on survival was also observed among patients with grade-I or -II tumors and patients with small tumors. In conclusion, DNA histogram type was a valuable prognostic factor in univariate analysis, and provided independent complementary information for patients considered at low or intermediate risk by classical pathological findings. |
| Databáze: | OpenAIRE |
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