A ‘photorelease, catch and photorelease’ strategy for bioconjugation utilizing a p-hydroxyphenacyl group
| Autor: | Dominik Madea, Tomáš Slanina, Petr Klán |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
Bioconjugation 010405 organic chemistry Chemistry Metals and Alloys Triazole Alkyne General Chemistry 010402 general chemistry Photochemistry 01 natural sciences Combinatorial chemistry Catalysis Cycloaddition 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound Materials Chemistry Ceramics and Composites Click chemistry Moiety Azide Bioorthogonal chemistry |
| Zdroj: | Chemical Communications. 52:12901-12904 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | A bioorthogonal 'catch and photorelease' strategy, which combines alkyne-azide cycloaddition between p-hydroxyphenacyl azide and alkyne derivatives to form a 1,2,3-triazole adduct and subsequent photochemical release of the triazole moiety via a photo-Favorskii rearrangement, is introduced. The first step can also involve photorelease of a strained alkyne and its Cu-free click reaction with azide. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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